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Author: Subject: Cobalt-Catalyzed Hydroazidation of Safrole
Lego
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[*] posted on 20-7-2007 at 14:13
Cobalt-Catalyzed Hydroazidation of Safrole


Cobalt-Catalyzed Hydroazidation of Olefins: Convenient Access to Alkyl Azides
Jérôme Waser, Hisanori Nambu, and Erick M. Carreira
J. Am. Chem. Soc., 2005, 127(23), 8294-8295
DOI:10.1021/ja052164r
Supporting information



Safrole is converted in 65% yield.

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Sandmeyer
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[*] posted on 20-7-2007 at 14:24


IMO, regarding MDxA synthesis that is an academic curiosity, the method might be more useful for synthesis of some phentermine compounds, if at all...

[Edited on 20-7-2007 by Sandmeyer]




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[*] posted on 6-8-2007 at 15:07


Nice. The azide is a great jumping off point for all types of functional groups, tho I assume that the azide is then converted to the amine. Is there a reaction(s) that might be subsequently utilized to create the methyl-amine instead of the amphetamine?

[Edited on 8/6/07 by Flip]
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