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Author: Subject: pH ~8 buffer
soma
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[*] posted on 3-10-2018 at 05:26
pH ~8 buffer


I'm looking for a buffer solution that would be suitable for eye drops at a pH of ~8.

Suggestions?

Thanks.
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Tsjerk
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[*] posted on 3-10-2018 at 05:48


Either phosphate or citrate.

https://www.google.nl/url?sa=t&source=web&rct=j&url=https://www.aaojournal.org/article/S1529-1839(04)70035-4/pdf&ved=2ahUKEwj6hNXWs-rd AhWJaFAKHW53B1gQFjADegQIAhAB&usg=AOvVaw16v0xUSOd5qUJWgS30na0S
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fusso
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[*] posted on 3-10-2018 at 05:51


How come this is in radiochemistry?



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pantone159
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[*] posted on 3-10-2018 at 06:30


Some eye drops (e.g. 'Visine') use a borate buffer.
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soma
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[*] posted on 3-10-2018 at 07:18


I was trying to post in "biochemistry". But thanks for the replies.
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3-10-2018 at 11:29
Metacelsus
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[*] posted on 29-12-2018 at 22:07


If you are making eye drops, be careful to ensure sterility. You wouldn't want to get any nasty eye infections.



As below, so above.
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Tsjerk
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[*] posted on 30-12-2018 at 00:19


Sterilization through autoclaving is easy, if you don't have an autoclave (pressure cooker) you can also cook it au bain-marie.
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[*] posted on 30-12-2018 at 10:24


Not your question, but make sure to match osmolality as well. OTC solutions for lenses contain a borate buffer. pH 8 is at the lower end of the range in which borate has useful buffer capacity (pH 8-10)

Out of curiosity, why would you want to make eye drops yourself?

Because this was previously in radiochemistry, I thought you might be trying to prepare an atropine eye-drop solution, as people did in the early days of research on radioactivity. They used to drop atropine solution in their eyes to widen their pupils, which allowed them to see alpha-particle scintillations more readily.




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