Originally posted by Bronstein
In Organic Reactions volume 5 there is a review on the leuckart reaction (I think there is a scan of that chapter somewhere on the internet). There is
an example of an experimental procedure using DMF, with furfural as the aldehyde. Not an aliphatic aldehyde, but still.
It seems that you get the desired amine directly when using DMF, no need to hydrolise the amide that forms otherwise. |