Sciencemadness Discussion Board

Fluorouracil synthesis?

Nixie - 12-1-2009 at 11:07

I have had some knuckle pads for around two years now, and the dermatologist said there is no effective treatment (knuckle pads are a keratodermal thickening of the skin at finger joint positions without established cause). They're not disabling but uncomfortable and if I don't bite them or file them down, they tend to grow further and eventually crack, which can be painful or bleeding.

I have read a recent paper about a promising treatment option using fluorouracil ( ), but this is still too new and even if I convince the dermatologist to do it, there is no way my medical coverage would pay for it, and there is no way I can afford it at this point or in the near future. Thus, I would like to synthesize it, and I'm asking for help here as to how to go about that. I normally have access to only OTC substances, but with some effort and risk might be able to acquire other reagents.

Ozonelabs - 12-1-2009 at 11:26

Perhaps this will be of some use to you:

Found with just a few moments using google. I shall consult with my lab partner on this synthesis to see whether we have immediately available the required chemicals to conduct this procedure.


stoichiometric_steve - 12-1-2009 at 11:27

Put the effort into buying the real thing. Yet, the ingestion of the raw material would be a violation of certain laws i guess.

Nixie - 12-1-2009 at 13:30

Pardon? You do not ingest it--you put it in the affected skin area.

The only affordable I see is very low concentration cream. Assuming I can find an online pharmacy that will ship to Canada without prescription (and I haven't yet), I'd still need a way to extract the substance from the cream, as the application described in the paper referenced is intralesional, not topical.

Ozone, kindly let me know what you find out.