Sciencemadness Discussion Board

nicotinic acid/nicotinamide analogue

D4RR3N - 5-4-2019 at 09:36

There is a supplement I am interested in taking for its health benefits. Its called nicotinamide riboside. Its a modified form of vitamin B3.
Only problem is that it is outrageously expensive So I was thinking what would be the likely product of mixing inexpensive nicotinic acid or nicotinamide with D Ribose powder in water?

brubei - 5-4-2019 at 14:01

Quote: Originally posted by D4RR3N  
So I was thinking what would be the likely product of mixing inexpensive nicotinic acid or nicotinamide with D Ribose powder in water?
a perfect placebo

Here is the synth
https://patentimages.storage.googleapis.com/f9/2d/be/487aebe...

p28
https://patentimages.storage.googleapis.com/d6/9a/71/8e2d849...

https://patentimages.storage.googleapis.com/64/45/ba/87bfab9...
https://patents.google.com/?q=Nicotinamide+riboside&oq=+...

[Edited on 5-4-2019 by brubei]

[Edited on 5-4-2019 by brubei]

D4RR3N - 7-4-2019 at 15:56

Quote: Originally posted by brubei  
Quote: Originally posted by D4RR3N  
So I was thinking what would be the likely product of mixing inexpensive nicotinic acid or nicotinamide with D Ribose powder in water?
a perfect placebo

Here is the synth
https://patentimages.storage.googleapis.com/f9/2d/be/487aebe...

p28
https://patentimages.storage.googleapis.com/d6/9a/71/8e2d849...

https://patentimages.storage.googleapis.com/64/45/ba/87bfab9...
https://patents.google.com/?q=Nicotinamide+riboside&oq=+...

[Edited on 5-4-2019 by brubei]

[Edited on 5-4-2019 by brubei]


Thanks for that brubei, I was not that far off though?

nic-ribo.jpg - 25kBnic-ribo1.jpg - 33kB

brubei - 7-4-2019 at 22:35

yep just add phosphate and enjoy

D4RR3N - 8-4-2019 at 04:35

I have been searching for any confirmation that D-Ribose can be converted to alpha d-ribose-1-phosphate by adding a phosphate source, so far can not find anything. Dilute Phosphoric acid is commonly used in fizzy drinks so was thinking of using that.

I suspect however it will be more complicated than that :D

[Edited on 8-4-2019 by D4RR3N]