Sciencemadness Discussion Board

Efficient low tech way to distinguish isomers

Monoamine - 2-8-2023 at 09:36

what are some ways in which you can distinguish isomers of two molecules that have the same molecular formula.

I can do TLC, but this al requires available analytical standard...

NMR would solve the problem, but obviously that's not a option for me.

Any insights would help.

Texium - 2-8-2023 at 10:03

Melting point or boiling point. Assuming you’re referring to regioisomers or diastereomers, and not enantiomers, as those would only be differentiable by polarimetry.

[Edited on 8-2-2023 by Texium]

DraconicAcid - 2-8-2023 at 10:05

That would depend on what kind of isomers you have.

If you want to distinguish the four isomers of butanol, you can see what they oxidize to- two will oxidize to carboxylic acids, one to a ketone, and the other one won't.

If you want to distinguish the three nitrophenols, look at mps.

If you want to distinguish the various isomers of C5H10Cl2, you're SOL.