Maui3 - 29-12-2024 at 12:41
How likely is the HCl generated in friedels craft alkylation to cleave a methylenedioxy group?
Maui3 - 29-12-2024 at 12:43
For reference I am talking about doing a FC-alkylation with benzodioxole and ethyl chloride.
Nemo_Tenetur - 30-1-2025 at 15:52
I´ve done some Friedel-Crafts-acylations (not alkylations) in the past. The generated HCl isn´t the problem, but the used anhydrous aluminum
chloride as catalyst. The catalyst destroyed the MD-bridge even at minus 20 degree centigrade. Then I switched to anhydrous tin tetrachloride (nasty
stuff by the way) in dichloromethane as solvent at room temperature and got after an hour about 40 - 45 % yield.