Adas - 6-9-2012 at 07:42
Hi guys!
I have read about Phenylethylamine used as an antidepressant on a drug forum. Most people claimed, that it is metabolised too fast and either large
quantities are needed, or you must also take MAOI (taking more than 1 gram PEA can create toxic metabolites, from what I've read).
But despite its very short duration, they said that it has perfect anti-depressant properties (and it is a body's natural compound).
I wondered if it is possible to make a compound that has relatively long half-life and slowly metabolizes into PEA. It would be a great help for those
suffering of depression, IMO.
Let's discuss this!
Rich_Insane - 6-9-2012 at 08:12
I wonder if N-acetylation might allow for the creation of a prodrug. Or perhaps substitution on the phenyl portion might make it more difficult to
metabolize...
AirCowPeaCock - 6-9-2012 at 17:24
PiHKAL anyone?
jon - 6-9-2012 at 18:27
l- dopa does the same thing trust me i got some and i know.
AirCowPeaCock - 6-9-2012 at 18:44
L-DOPA is the prodrug that crosses the BBB. But I've heard mixed reports about its effectiveness.
Adas - 7-9-2012 at 06:13
L-DOPA is the prodrug of dopamine, not PEA...
Maybe 2-amino-3-phenylpropanoic acid would be a good prodrug of PEA.
jon - 8-9-2012 at 10:53
using the l-dopa analogy sounds plausible indeed.
less h-bonding sites too, looks like it could breakdown, and cross the blood brain barrier with ease.
SM2 - 8-9-2012 at 11:40
Phenylethylamine is one carbon away from phenylisopropylamine, which is not so easily broken down by MAO. And amphetamine definately has an
anti-depressant effect, no doubt. Phenylethylamine will be taken off the market soon enough, however.
zed - 8-9-2012 at 11:45
Well, we used to try to get lots of tyrosine into the pipeline. Body uses it to produce dopamine. Cheap, works fairly well, some effectiveness at
alleviating Parkinson's symptoms.
ChemistryGhost - 9-9-2012 at 19:36
What about this?
http://en.wikipedia.org/wiki/%CE%91-Ethylphenethylamine
zed - 22-9-2012 at 12:36
There is a nomenclature problem inherent in this question.
Phenethylamine has the structure C6H5-CH2-CH2-NH2
The generic term Ethylphenethylamine gives no clue as to what actual structure you are referring to. Ethyl where? N-Ethyl(which might be assumed)?
Ortho, Meta, Para...Ethyl? 1-Ethyl?
Turns out you are referring to 1-Phenyl-2-Amino-Butane. An analog of 1-Phenyl-2-Amino-Propane....AKA Amphetamine.
Wikipedia may refer to this material simply as Ethylphenethylamine, but they are basically wrong.
In fact, since you made your posting, they have made a nomenclature correction. Still wrong, as in imprecise, but closer.
[Edited on 22-9-2012 by zed]