chemrox - 25-11-2012 at 23:20
Dehalogenations can be very useful to the amateur chemist who may have access to an OTC which he wishes to change and use as an intermediate. A lot
of these are catalytic transfer hydrogenations. Here are some examples I've found or been shown recently:
Attachment: CV3P0519.dechlorination of 2-Cl-lepidine in 1.5-2 hrs using noble metal catalyst and H2.pdf (158kB)
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I tried three but it went over the limit
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[Edited on 26-11-2012 by chemrox]
chemrox - 26-11-2012 at 16:15
here's another
Attachment: lepidine bwo cth.pdf (534kB)
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Doc B - 2-12-2012 at 21:23
I think it's an interesting technique useful to the amateur to use as you've mentioned.
jon - 23-12-2012 at 16:44
i used this method
1.2 eq potassium formate 5 mol % pd/c could be 5 could be 10% it goes the same
add 3 eq water any more and the rate is cut in half so be precise prestir.
for loperamide after prestirring the donor with the catalyst (reduces reaction time to 30 min)
i used freebase 1 gram and 50 ml dry ipa reflux until CO2 evol is no longer observed.
filter the alcohol with a fritted buchner funnel
wash the pd with 3% naoh and water until neutral to recycle (can be used 30 times)
evap the ipa down partition between water and dcm wash dcm and evap dcm i then esterify with propionic anhydride.
this to some weird prodine methadone analog it acts more like methadone i got bombed on it my pupils stayed pinned until next day all day it kept me
good a long time
jon, you have a U2U
SM2 - 15-8-2014 at 01:59
waiting to reply.