Bonee - 3-3-2014 at 00:22
Is there any rationale lowering the temperature of a FC acylation to -70?
and doing it in a dry ice/acetone bath?
most preps are doing it at 0, but then other people use -70...
I couldn't find anything about it on the net or in books...
Chemosynthesis - 3-3-2014 at 00:30
Is there a noticeable difference in reaction scale between the two temperatures?
Bonee - 3-3-2014 at 03:09
no, not really, that's why i am curious
true that it may be easier to control a bigger batch with lower temperatures.
but is there any literature involving increased yield, or anything else?