Sciencemadness Discussion Board

2,6-dichlororo pyridine 4 carboxilic acid reduction to isonicotinic acid

Aqua-regia - 10-4-2014 at 07:19


I am looking to synthesize isonicotinic acid from citrazinic acid. The route to get 2,6-dichloro-pyridine-4 carboxilic acid was easy, but the reduction of halogen need a cheap procedure. (no hydrazine and LiAlH) A little bit of preliminary googling I found this:


What is your opinion about this things

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Weinreb - 10-4-2014 at 10:33

I have performed the Mg/isopropyl alcohol reduction on chlorobenzene, yield was excellent on this substrate. The magnesium was standard turnings used for Grignard reactions.

Aqua-regia - 10-4-2014 at 23:46

Thank you, its sounds good. I hope that the pyridine ring don't occurse barrier, or formed dipyridine bond and no spherical inhibition.

Dr.Bob - 11-4-2014 at 07:19

Quote: Originally posted by Aqua-regia  
Thank you, its sounds good. I hope that the pyridine ring don't occurse barrier, or formed dipyridine bond and no spherical inhibition.


Huh?