Originally posted by a123x
The second idea was to try a completely different route. I was thinking of nitration, reduction of the nitro group, and then diazotization in water to
give an OH group. In addition, I think doing the same thing in the corresponding alcohol can actually give the methoxy or ethoxy group although I only
have come across one reference to such being used. My main concern here is that the nitration won't go well. I'm thinking it might oxidize
the aldehyde group even in the case of vanillin which shouldn't require terrible severe conditions to nitrate since the OH is strongly activating
to the ring.
Any thoughts or comments would be greatly appreciated. |