kamal - 14-2-2006 at 20:27
Hi to all friends !
AGAIN !
I'm trying one reaction of making a Michael adduct by reacting an Acrylate based ketoester with l-alanine, but not having proper process references
for this.
Can I get some experimental/synthesis references for this reaction ?
Awaiting your nice suggetions !!
Regards,
Kamal
(mailbox@prolificint.com)
Sriraman - 28-3-2006 at 06:52
3-chloropropionitrile - Michael addition with sulfanamide is done bytaking excess of 3-chloropropionitrile with HCl gas purging at 55 deg C.
kamal - 29-3-2006 at 08:36
Sorry but I couldn't get your point.......
Sriraman - 29-3-2006 at 17:59
If you are looking for Michael addition across -CN to-C=NH
such michael additions are reported in some patents.
Sriraman
Sriraman - 11-5-2006 at 00:01
A procedure for Michael addition - Please refer US ptent 4731479