Sriraman - 1-5-2006 at 02:19
Sesloratadine is a metabolite of Loratadine, which is prepared from Loratadine by hydrolysis and decarboxylation. The produt has tendency to delop
pink coloration. can some one suggest whi this develops pink colour and howto prevent it.
Sriraman
chemoleo - 1-5-2006 at 15:34
Ok...how about Wiki:
Desloratidine
http://en.wikipedia.org/wiki/Desloratadine
Loratidine
http://en.wikipedia.org/wiki/Loratadine
Why would it be pink, in case of the desloratidine?
Unlike Loratidine, Desloratidine is basic, so it will form salts with acids. Either these salts are coloured (unlikely), or the free base is coloured.
It depends very much on how the desloratidine is shipped, is it as the hydrochloride?
PS I find the structural similarity to some other compounds quite interesting... I seem to remember having seen this structure in context with an
antidepressant - anyone remembers it?
Sandmeyer - 1-5-2006 at 18:09
Interesting, these compounds look like good ol' tricyclic antidepressants.
Off topic;
Ah those were the days, now this compound (Amineptine) is considered too fun to be given to people, hence it was removed from the market. It didn't
have the common side-effects found in tricyclics and I know someone who has been on it for 3 years on daily basis without problems, it is simply the
best antidepressant according to him and he has tried many (including street-stimulantia). Too bad this compound was removed as it actually could help
people with depression.
[Edited on 2-5-2006 by Sandmeyer]
Polverone - 5-5-2006 at 18:24
I received this as a "reported post" from Sriraman; it was probably meant to be a reply:
Desloratadine is shipped as a base only and hence is the colour development is a concern. The product when it is formed is white and when crystallised
from solvents gets pink colour.