Sciencemadness Discussion Board

NRX-1074

Charlie80 - 28-4-2015 at 05:49

I'm looking to identify a compound called nrx-1074. Also looking to find synthesis pathway.
It may be hidden here:
https://www.google.com/patents/WO2010033757A1?cl=en&dq=n...

Any leads welcome. There may be compensation for those who strike gold.

Loptr - 28-4-2015 at 11:51

It sounds like the company hasn't released any more details on the compound. NRX-1074 might be a public release codename so that it can't be matched up to any patents easily. It probably has already been patented and easily available if you read the patents, but they aren't going to tell you which one it is.

I also found there is a lot of freakin' interest in this compound just by a quick google search. It looks like it might be similar to ketamine, except with nootropic function? The longecity forum has several threads about it.

EDIT: Patent WO2014120783 A1 mentions NRX-1076, so it might be close to that timeframe of being published. Filed Jan 2014, and published Aug 2014.

[Edited on 28-4-2015 by Loptr]

IrC - 28-4-2015 at 12:31

Do not understand why someone would be searching for the synthesis of something they know nothing about. Are we not wishing to state what it is we know thus requiring subterfuge?

http://www.freepatentsonline.com/result.html?sort=relevance&...

I imagine it is obvious anyone finding gold is rewarded with... gold.

Loptr - 28-4-2015 at 12:37

Quote: Originally posted by IrC  
Do not understand why someone would be searching for the synthesis of something they know nothing about. Are we not wishing to state what it is we know thus requiring subterfuge?

http://www.freepatentsonline.com/result.html?sort=relevance&...

I imagine it is obvious anyone finding gold is rewarded with... gold.


I just figured I would find it and then force them to pay before handing it over. :P

IrC - 28-4-2015 at 12:42

Good idea. I was posting to the OP when I concluded it appears they for some reason are not really saying what they knew about the 'mysterious compound'.

http://en.wikipedia.org/wiki/NRX-1074

Loptr - 28-4-2015 at 12:59

Right now I think I know as much about NRX-1074 as anyone outside the company. I have found related work that isn't owned by Naurex Inc. that might be related to NRX-1074, which is from a previous institution.

In other news, it seems that GLYX-13 has had its patent extended to 2030. Good for them.

Not to mention that NRX-1074 seems to be an oral formulation of their GLYX-13 (intravenous) product. ;)

[Edited on 28-4-2015 by Loptr]

redan-yadayada - 22-9-2015 at 10:40

The structure of this compound has been disclosed in this paper. Could anyone help me with a synthesis route for the unusual intermediates?

Thank you.

[Edited on 22-9-2015 by redan-yadayada]

aga - 22-9-2015 at 10:51

Quote: Originally posted by redan-yadayada  
Could anyone help me with a synthesis route for the unusual intermediates?

Yes.

No idea who they are, but there are people that could help.

Dan Vizine - 2-10-2015 at 07:18

redan-yadayada,

Seeing as the paper is 203 pages long, and I have more ambition than time, would you please indicate which page the structure is on?

[Edited on 2-10-2015 by Dan Vizine]

deltaH - 2-10-2015 at 08:14

Quote:
NRX-1074 (threonyl-prolyl-2R-(2-benzyl)-prolyl-threonine amide) has
the same tetrapeptide sequence as rapastinel (GLYX-13) except that the second Pro is
benzylated.


Supporting info:

rapastinal.jpg - 23kB

[Edited on 2-10-2015 by deltaH]

Dan Vizine - 2-10-2015 at 13:37

Quote: Originally posted by Charlie80  
I'm looking to identify a compound called nrx-1074. Also looking to find synthesis pathway.
It may be hidden here:
https://www.google.com/patents/WO2010033757A1?cl=en&dq=n...

Any leads welcome. There may be compensation for those who strike gold.


Good luck in your search. Maybe someone will have access to the synthetic papers referenced in your link.