Sciencemadness Discussion Board

2,4-Thiazoledione

chemwizard - 26-9-2006 at 21:25

Could anybody suggest the synthetic method of 2,4-Thiazoledione........which is one of the raw materials for Pioglitazone and Rosiglitazone?

Thanks a lot.

solo - 27-9-2006 at 03:33

Studies on the Synthesis of Some Substituted Flavonyl Thiazolidinedione Derivatives-
Oya BOZDA G? , Gulgun AYHAN-KILCIG I?L, Meral TUNÇB I?LEK, Rahmiye ERTAN
Turk J Chem 23 (1999) , 163 – 169.

Abstract
Synthesis and some physico-chemical properties of five flavonyl thiazolidinedione derivatives are described. These products were synthesized by Knoevenagel condensation from flavone-6-carboxaldehyde and 3-substituted 2,4 thiazolidinediones.

Attachment: Studies on the Synthesis of Some Substituted Flavonyl Thiazolidinedione Derivatives-I.pdf (79kB)
This file has been downloaded 736 times