smartgene - 25-8-2016 at 15:15
what is the best reagent to do a monochlorination on the alpha position of a ketone with minimum side reaction like di tri
Dany - 25-8-2016 at 15:44
Treating of a ketone with lithium diisopropylamide (LDA) followed by p-toluenesulfonyl chloride (p-TsCl) gives α-chloroketone. This method has been
described by Brummond & Gesenberg (see attached file and references therein).
Dany.
Attachment: a-Chlorination of Ketones.pdf (19kB)
This file has been downloaded 272 times
[Edited on 25-8-2016 by Dany]
smartgene - 25-8-2016 at 16:57
Im looking for a reagent that can easily prepared
AvBaeyer - 25-8-2016 at 19:28
This can be easily accomplished using TCCA with an acid catalyst (chloroketone) or with 1,3-dibromo-5,5-dimethylhydantoin (non-cholorine pool
treatment) to give the bromoketone again with an acid catalyst. There are several accesible free references on this if you do a google/google scholar
search.
AvB
PHILOU Zrealone - 26-8-2016 at 09:35
Cl2/HCl is also sometimes used like for chloropropanone see "The War Gases: Chemistry and Analysis" book into the Library.