Originally posted by chemrox
The reaction mixture is then diluted with dichloromethane and washed with 4% aqueous (woops but probably no biggy) sodium hydroxide solution followed
by water. The organic phase was then shaken with 2N HCl. The organic layer was separated and the aqueous layer was extracted with DCM. Combined
organic phase was dried over sodium sulfate and concentrated to yield the crude HCl salt.
Two notes:
the product is soluble in DCM and the "shake with 2N HCl" is an acidification to make the HCl salt.
why Na2SO4 instead of MgSO4? isn't the latter a lot quicker? certainly cheap and available anywhere.. just heat Epsom salts.
Your insights are greatly appreciated and sought after.
[Edited on 1-4-2007 by chemrox] |