Journal of Hazardous Materials
Volume 126, Issues 1-3, 11 November 2005, Pages 1-7
Related Articles in ScienceDirect
On the explosive properties of 1H-benzotriazole and 1H-1,2,3-triazole
Tetrahedron Letters, Volume 48, Issue 7, 12 February 2007, Pages 1233-1235
Marcus Malow, Klaus D. Wehrstedt, Steffen Neuenfeld
Abstract
For 1H-benzotriazole, no explosive properties are observable, but the relative high exothermic decomposition energy of 1590 J/g should be kept in
mind. Nevertheless, an endothermic melting barrier at 100 °C ensures safe handling at lower temperatures. For 1H-1,2,3-triazole, the exothermic
decomposition energy is as high as 2600 J/g, but explosive properties are also not detectable. Therefore, both reagents are hazardous with regard to
the exothermic decomposition potential and can be handled safely with precautions.
Tetrahedron, Volume 57, Issue 12, 17 March 2001, Pages
Copyright © 2005 Elsevier B.V. All rights reserved.
Explosive properties of 1-hydroxybenzotriazoles
K.D. Wehrstedta, , , P.A. Wandreya and D. Heitkampb
Bundesanstalt für Materialforschung und -prüfung (BAM), Working Group “Explosive Substances of Chemical Industries”, Unter den Eichen 87,
D-12205 Berlin, Germany bBayer Industry Services, BIS SUA VA, D-51368 Leverkusen, Germany
Abstract
1-Hydroxybenzotriazole and its derivatives are widely used as peptide coupling reagents. However, people are often not aware that such compounds show
explosive properties when heated under defined confinement or when subjected to mechanical stimulus. 1-Hydroxybenzotriazole (HOBt) is able to
propagate a detonation when a stronger booster is used. Sometimes explosive substances are desensitized to suppress their hazardous properties, yet
depending on the amount and nature of desensitizer, the result is often not quite satisfactory.
During the last years, some 1-hydroxybenzotriazoles were tested at BAM. The results are presented in this paper.
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