harveyclayton
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Benzalkonium chloride PTC?
Just wondering what you thought about using benzalkonium chloride as a phase transfer catalyst?
It is alkylbenzyldimethylamine chloride, where the alkyl group can vary. Thus it should be fairly soluble in non-polar solvents, and could therefore
be used as a PTC, for example when performing NS on haloalkanes.
It is found in many OTC algaecides.
That's all, what do you think?
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ZetekitoxinAB
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It seems plausible to try; how do you intend to do your NS? I would think the best yields would be obtained in anhydrous conditions; for example
reflux a primary haloalkane with dry KCN in a polar anhydrous solvent (DMF, DMSO, absolute etanol) with 18 crown 6 as a catalyst.
The problem with Benzalkonium is that it is very hygroscopic and difficult to dry; isolating it pure from commercial products would also be
troublesome.
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ZetekitoxinAB
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I made a mistake in my post above; NS could easily be done between aqueous and organic layer using PTC; your best bet is to use a drop or two of a
concentrated benzalkonium solution
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