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Author: Subject: Henry Reaction
fuming_nitric_acid
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[*] posted on 23-7-2008 at 12:55
Henry Reaction

In an Henry (Nitroaldol) reaction
As far as I know milder reaction conditions forms Niro-Alcohols while harsher ones cause dehydration forming Nitro-Alkenes...

After the base is neutralized is the Nitro-Alcohol still suspectible to dehydration (can he dehydrate) if he faces harsh conditions? (For example can he be distilled?)


[Edited on 23-7-2008 by fuming_nitric_acid]
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[*] posted on 23-7-2008 at 13:07


There is a lot of info regarding this available.

IIRC, tertiary amines are used as catalyst if you want the amino alcohol. Some dehydration is alsways possible, if there are traces of acids or bases, so any distn should be done with a good vacuum (if it's even possible..).
If you neutralize the base with a strong acid, dehydration is bound to happen.



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fuming_nitric_acid
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[*] posted on 23-7-2008 at 20:03


No I'm talking about after we isolate the Nitro-Alcohol in his pure form can we distill him?
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[*] posted on 23-7-2008 at 23:58


Have you searched Chemical Reviews?

Or the Organic Reactions series?

Or the named reactions section of Merck Index?

Some of this is in forum library, much more is in ftp, members have worked hard to make these fine references available for free.

So use them.

In the New Book thread (Organic Chemistry) there's a volume on Named Reactions.

Download it.

If you googled for Henry nitroaldol reaction you would get a summary and references to follow.

There is no shortage of accessible information about this. Go fetch.



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[*] posted on 26-7-2008 at 15:27


But that forum is password protected! What's the password?
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