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Author: Subject: How many indole alkaloids in natural products?
gogo
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[*] posted on 14-5-2009 at 04:09
How many indole alkaloids in natural products?


Is there any analysis on the proportion of indole alkaloids in natural products?
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Barium
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[*] posted on 14-5-2009 at 04:15


Do you mind specifying which natural product/s you are talking about? You don't believe there is a general answer to your question, do you?
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gogo
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[*] posted on 14-5-2009 at 04:43


I just want to know the proportion of indole and its derivatives in nature, I do not mean to know the exact number of the compounds.
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jokull
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[*] posted on 14-5-2009 at 05:13


Hi,
I'm afraid that your question is quite vague.
Maybe it would be clearer if you refer to an specific plant. Coffee it is not the same than lettuce.
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Sauron
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[*] posted on 14-5-2009 at 06:15


How many indole angels can dance on the head of a pin?

The question can be answered obly by using C.A. and crossindexing "indole alkaloids" with "natural products"

It's gibberish as search terms for starters. All alkaloids are by definition nitrogenous natural products. So simply ask "How many indole alkaloids are there? and exclude synthetic derivatives.

Amyway without recourse to C.A. database, the question in unanswerably vague.




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Nicodem
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[*] posted on 14-5-2009 at 09:21


Unfortunately, as it is now, this is unanswerable even by doing a SciFinder/CA search since this database does not index the slucidated structure of proteins and glucosides which are obviously also natural products. Since almost all proteins contain an indole moiety (tryptophan residue) and since the number of sequenced proteins is getting enormous, doing only a Chemical abstracts search is not enough. Also, this database is not reliably complete with labels indicating what is and what is not a natural product, so obtaining a relevant number with at least +/- 50% confidence would be anything but simple. This question is not only too vague to be answered, it is also too difficult to answer even if the restrictions would be specified.



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olmpiad
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[*] posted on 15-5-2009 at 09:44


Try looking through Phytochemical Databases. One that I find quite useful is Dr. Duke's Phytochemical Database (http://www.ars-grin.gov/duke/), as it allows you to search for plants via latin and common names, and also allows you to search for certain activities for a plant (i.e. antiviral). You can also search by chemical name, although this function doesn't always work the best. Indoles are everywhere in the plant world however, so you really are going to have to get more specifications if you need a good answer! =]
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