DNA
Hazard to Others
Posts: 191
Registered: 11-6-2003
Location: @moon
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Mood: Experimenting
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Isozyme picture wrong
Can anyone see what is wrong in this picture?
And also explain why it is wrong please?
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chemoleo
Biochemicus Energeticus
Posts: 3005
Registered: 23-7-2003
Location: England Germany
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Mood: crystalline
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There's one cell type here that is different to all the others. Which one is it?
Therein lies the answer! Or so I suspect.
See http://en.wikipedia.org/wiki/Lactate_dehydrogenase , look what it does and what it needs for activity ..and go and figure!
Le'ts see what you come up with 
[Edited on 12-1-2010 by chemoleo]
Never Stop to Begin, and Never Begin to Stop...
Tolerance is good. But not with the intolerant! (Wilhelm Busch)
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DNA
Hazard to Others
Posts: 191
Registered: 11-6-2003
Location: @moon
Member Is Offline
Mood: Experimenting
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LDH-1 (4H) - in the heart
LDH-2 (3H1M) - in the reticuloendothelial system
LDH-3 (2H2M) - in the lungs
LDH-4 (1H3M) - in the kidneys
LDH-5 (4M) - in the liver and striated muscle
Are all there but the leukocyte isn't.
But rather I'dd think there should be a big dash at H4 instead of the very little one.
I already need to answer for tomorrow morning to get extra points for my exam.
Could you please tell me what's wrong and if my conclusion is correct?
[Edited on 13-1-2010 by DNA]
[Edited on 13-1-2010 by DNA]
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chemoleo
Biochemicus Energeticus
Posts: 3005
Registered: 23-7-2003
Location: England Germany
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Mood: crystalline
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You left out the red blood cells.
I haven't researched this properly, that's your job - but consider this:
Erythrocytes are anucleate, they don't have mitochondria, ER and Golgi.
The important bit is the mitochondria - no mitochondria, no glycolysis, Krebs cycle, electron transport, mitochondrial proton pumps, et cetera.
LDH needs NADH, where would it come from if there aren't mitochondria to generate it?
I might be wrong because like I said, I haven't researched it, but erythrocytes are so dissimilar to all the other cell types (every other one of
these have all the cellular organelles) that I don't think these factors are a coincidence.
Think/read about it with this in mind, and good luck with your decision!
Never Stop to Begin, and Never Begin to Stop...
Tolerance is good. But not with the intolerant! (Wilhelm Busch)
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