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Author: Subject: Diphenhydramine hydrochloride
Globey
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[*] posted on 16-8-2010 at 08:54


I'm more interested in the de-syntheses if things like diphenhydramine. What reagents can one tease apart;)
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Picric-A
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[*] posted on 24-9-2010 at 10:27


I would just like to update this thread.
After my LONG efforts at trying to synthesise dimethylethanolamine i have found out it is extremly cheap and readily available as a vitamin!!
http://en.wikipedia.org/wiki/Dimethylethanolamine
If only i had found this out sooner!
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mario840
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[*] posted on 24-9-2010 at 10:58


but did you succesfull synthesised it ??
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Picric-A
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[*] posted on 24-9-2010 at 13:57


Yes, by reacting 2-chloroethanol with dimethylamine under reflux. Yields ok but cost of raw materials was much higher than the cost of buying the vitamin.
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mario840
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[*] posted on 25-9-2010 at 01:22


is there any patent for making dimethylethanolamine from 2-chloroethanol and dimethylamine ? or you just work it out ?
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[*] posted on 25-9-2010 at 04:41


I didnt find a patent for this specific reaction however there were many patents with similar reactions.
2-chloroethanol was refluxed with an excess of a solution of dimethylamine in ethanol, followed by evaporation and fractionating the oil residue udner vacuum.
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mario840
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[*] posted on 25-9-2010 at 04:48


thanks men !! :)
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