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Author: Subject: Methylation of 5-htp to melatonin
mackolol
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[*] posted on 21-6-2019 at 09:43
Methylation of 5-htp to melatonin


Hi, I'm wondering if one could methylate 5htp to melatonin using for example methyl iodide, would it work, and how should it be done? I can't find any informations about it in internet. Also wouldn't it methylate also amide group?
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zed
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[*] posted on 21-6-2019 at 14:51


https://en.wikipedia.org/wiki/Melatonin
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karlos³
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[*] posted on 21-6-2019 at 14:58


What zed wants to say is, 5-HTP is an amino acid, and melatonin is an acetylamide.

You can surely turn 5-HTP into 5-methoxytryptophan, decarboxylate that and acetylate the amine to get melatonin.
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mackolol
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[*] posted on 22-6-2019 at 00:55


Oh sorry, my bad I thought that melatonin is methoxy tryptophan. So how would I methylate that stuff just to methoxy tryptophan?
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karlos³
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[*] posted on 22-6-2019 at 03:25


Probably like you would methylate a phenol too.
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