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Author: Subject: Ethanol and methanol interchangeability?
Fyndium
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[*] posted on 21-7-2021 at 11:53
Ethanol and methanol interchangeability?


Again, there is an instance where I stock small amount of methanol, but I can get ethanol OTC cheaply. Closest store that supplies methanol is over 200km away and shows 0 on stock. This might be a bit of a general side of question, but how subtitutable ethanol is for methanol as a reaction solvent? I know for a fact that it works well for many reactions where ethanol, methanol, isopropanol, etc can be used in a very similar manner. The reaction is not water sensitive at all, actually the opposite, so 95% ethanol would not be an issue in any extent.

Could I simply test this by attempting to dissolve a little amount of reactants and see how it goes from there, and then scale up if all is ok?
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Oxy
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[*] posted on 21-7-2021 at 12:25


I used absolute ethanol with success as a replacement of methanol as a solvent. However, for some reactions where solvent polarity was a key factor the difference in yield was very visible.
A significant water content may not affect the reaction itself but can make the process worse by decreasing of solubility of compounds which are not soluble in water but are soluble in methanol or ethanol.
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Amos
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[*] posted on 21-7-2021 at 17:18


The best way to get a specific answer is to ask a specific question. Any idea what reaction you'll be attempting should you proceed with ethanol?
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[*] posted on 21-7-2021 at 17:39


Sometimes they are interchangable, and sometimes they aren't.

It depends on the reaction.
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[*] posted on 21-7-2021 at 23:55


Quote: Originally posted by Fyndium  


Could I simply test this by attempting to dissolve a little amount of reactants and see how it goes from there, and then scale up if all is ok?

Almost certainly.
That sort of thing is called science.
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