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Author: Subject: Possible enatioselective phenylacetylcarbinol synthesis ?
slyder
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[*] posted on 5-9-2021 at 06:19
Possible enatioselective phenylacetylcarbinol synthesis ?


Hello,

Can someone confirm would this synthesis work in order to obtain enatioselective ( ee 99% ) R-PAC from R-mandelic acid --> Weinerb amide --> methyl grignard ---> R-PAC ?

Thanks !

Cheers ! :)





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Texium
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[*] posted on 5-9-2021 at 07:22


It should work if you protect the alcohol first.



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slyder
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[*] posted on 5-9-2021 at 07:49


Texium thanks for reply.

Protection with sillyl group eg. tert-Butyldimethylsilyl chloride ( TBDMSCl ) or tetrahydropyranyl ether will be OK in my opionion because is the most easiest to remove ?
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