Maui3
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Does Anyone Have Experience With Thermal Decarboxylation of Phenylalanine Without The Use Of Cyclohexanol or Cyclohexanone?
I was wondering if anyone has experience with thermal decarboxylation of phenylalanine without the use of cyclohexanol or cyclohexanone?
I thought maybe acetophenone could be used, since it has a high boiling point as well as being a ketone? .. but I am unsure of this.
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Pumukli
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Acetophenone works most of the time in amino acid decarboxylations.
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zed
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Ummm. Cyclohexanone, as I recall, is hard to come-by; it beings on one of the restricted chemical lists.
Some have reported Peppermint oil as being a useful catalyst.
It occurs to me, that Camphor might be useful also.
Pretty stinky, but not in an extremely offensive way.
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Maui3
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I'll try with acetophenone, and one with mint oil catalyst. I am pretty sure it's spearmint oil, actually. Since peppermint oil, as far as I know,
does not contain the catalyst carvone. But not quite sure on that..
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Fery
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I did a decarboxyllation of proline in acetophenone (used as a solvent as well as a catalyst). My yield was around 50%. https://www.sciencemadness.org/whisper/viewthread.php?tid=64...
Catalyst from from spearmint oil is L-carvone. You can use it in higher boiling point solvent (like turpentine oil = pinene). It is possible to
prepare it synthetically from D-limonene (3-step synthesis) -> ... -> L-carvone = R-(-)-carvone https://www.sciencemadness.org/whisper/viewthread.php?tid=15...
maybe also D-carvone = S-(+)-carvone could work - steam distillation (or Clevenger apparatus) of caraway or dill seeds
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