Sciencemadness Discussion Board
Not logged in [Login ]
Go To Bottom

Printable Version  
Author: Subject: reductive dehalogenation of aromatic cmpds
chemrox
International Hazard
*****




Posts: 2929
Registered: 18-1-2007
Location: UTM
Member Is Offline

Mood: psychedelic

[*] posted on 25-11-2012 at 23:20
reductive dehalogenation of aromatic cmpds


Dehalogenations can be very useful to the amateur chemist who may have access to an OTC which he wishes to change and use as an intermediate. A lot of these are catalytic transfer hydrogenations. Here are some examples I've found or been shown recently:


Attachment: CV3P0519.dechlorination of 2-Cl-lepidine in 1.5-2 hrs using noble metal catalyst and H2.pdf (158kB)
This file has been downloaded 903 times
I tried three but it went over the limit
I'm hoping to add more in separate posts providing there is interest as demonstrated by others adding files here. Please don't use volatile file services that require registration. Thanks!

[Edited on 26-11-2012 by chemrox]




"Ignorance is the Mother of Devotion." — Robert Burton.
View user's profile View All Posts By User
Nicodem
Super Moderator
Thread Moved
26-11-2012 at 12:12
chemrox
International Hazard
*****




Posts: 2929
Registered: 18-1-2007
Location: UTM
Member Is Offline

Mood: psychedelic

[*] posted on 26-11-2012 at 16:15


here's another

Attachment: lepidine bwo cth.pdf (534kB)
This file has been downloaded 664 times





"Ignorance is the Mother of Devotion." — Robert Burton.
View user's profile View All Posts By User
Doc B
Hazard to Others
***




Posts: 107
Registered: 5-4-2012
Member Is Offline

Mood: No Mood

[*] posted on 2-12-2012 at 21:23


I think it's an interesting technique useful to the amateur to use as you've mentioned.
View user's profile View All Posts By User
jon
National Hazard
****




Posts: 455
Registered: 11-1-2006
Member Is Offline

Mood: paranoid distrustful apprehensive

[*] posted on 23-12-2012 at 16:44


i used this method

1.2 eq potassium formate 5 mol % pd/c could be 5 could be 10% it goes the same
add 3 eq water any more and the rate is cut in half so be precise prestir.
for loperamide after prestirring the donor with the catalyst (reduces reaction time to 30 min)
i used freebase 1 gram and 50 ml dry ipa reflux until CO2 evol is no longer observed.
filter the alcohol with a fritted buchner funnel

wash the pd with 3% naoh and water until neutral to recycle (can be used 30 times)
evap the ipa down partition between water and dcm wash dcm and evap dcm i then esterify with propionic anhydride.
this to some weird prodine methadone analog it acts more like methadone i got bombed on it my pupils stayed pinned until next day all day it kept me good a long time




Give me librium or give me meth!
Patrick Henry....
View user's profile View All Posts By User
SM2
National Hazard
****




Posts: 359
Registered: 8-5-2012
Location: the Irish Springs
Member Is Offline

Mood: Affect

[*] posted on 15-8-2014 at 01:59
jon, you have a U2U


waiting to reply.



"Old men who speak of victory
shed light upon their stolen life
they - drive by night- and act as if they're
moved by unheard music." B. Currie
View user's profile View All Posts By User

  Go To Top