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Author: Subject: The neurochemicals in nature
symboom
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[*] posted on 4-1-2021 at 23:04
Kanna extract analysis


Here is a report I got with my kanna extract

IMG_20210105_005525039~2.jpg - 1.3MB IMG_20210105_010027713_BURST000_COVER_TOP~2.jpg - 1.1MB

Here is an NMR of matrine and general information about the extract


IMG_20210105_011502016~2.jpg - 1.3MB IMG_20210105_011450520~2.jpg - 1.1MB

[Edited on 5-1-2021 by symboom]
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[*] posted on 5-1-2021 at 09:15


I really enjoy this thread. SM mostly stays away from "pharma type" chemicals and there's good reason for that. However, your effort of cataloging the various neurochemicals that plants and fungi naturally make is appreciated.

My favorite of your list so far is Hodgkinsine. I'd take a guess that it would replace kratom if kratom is fully illegal and scheduled.




"Read not to contradict and confute; nor to believe and take for granted; nor to find talk and discourse; but to weigh and consider." -Francis Bacon
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[*] posted on 5-1-2021 at 09:48



Thank you that's great to hear.
akuamma is normally used as the replacement of kratom In places where it is illegal it is very similar herb that is from Africa unlike Kratom which is from Asia. They are very similar in that they are both partial opioids.
I put a lot of effort in this thread I was frustrated that there is so little research being done on these plants due to synthetic equivalent compounds already existing but now researches are discovering that there are better and safer alternatives from nature
So little information is found about many of the herbs I think it has to do with cost if a pharma company need to make a compound it is made syntheticly rather than extracted
Here is the research on kratom compounds and why a future synthetic partial opioid based on the structure kratom is being considered.
(Synthetic because a plant can't be patented)
https://pubs.acs.org/doi/10.1021/jacs.6b00360

MGM-9 kratom synthetic analog
https://www.sciencedirect.com/science/article/abs/pii/S00283...
And other MGM compounds
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067406/


Hodgkinsine is unfortunately hard to find a lot of information about.

[Edited on 5-1-2021 by symboom]

[Edited on 6-1-2021 by symboom]
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[*] posted on 5-1-2021 at 12:39


I have almost two kilos of akuamma(I even got a fresh fruit directly from a German farmer in Ghana but sadly the seeds haven't germinated without going through an elephants digestive system) but I have to say, its not a replacement for kratom.
It is pretty good against pain and cold and the flu, and thats really where its strength is, but it is not an euphoric opioid in the same manner as kratom.
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symboom
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[*] posted on 10-3-2021 at 18:44


Serotonin //SRI
Dopamine //DRI
Noradrenaline // NRI
Cannabioid // CBRI
Opioid // ORI
Acetylcholine //CRI
Adenosine // AdRI
Glutamate
-NMDA/glycine // GRI
-AMPA
GABA
Histamine


--+--
#DOPAMINERGIC#
Phenylalanine - BB
Tyrosine - BB
Mucuna Pruriens/ L-Dopa - BB
Phenethylamine - BB
Flowering quence - DRI
Blue trumpet vine - DRI
Oroxylum indicum/ Oroxylin - DRI
Skullcap/ Oroxylin A - DRI
Sacred lotus/ Nuciferine- agonist
Blue lotus/Aporphine - agonist
sacred bamboo - antagonist
Vitex - Antagonist
Stephania intermedia /Tetrahydropalmatine - Antagonist
------
Armodafinil - DRI
Modafinil - DRI
Adrafinil - DRI
Phenylpiracetam (NDRI)
___________________
# SEROTONERIC#
Lithium Carbonate
Tryptophan - BB
5HTP - BB
Sam_e - BB
Saffron - SRI
Kanna / mesembrine - SRI
St. John's wort - monoamine reuptake inhibitor (MRI)
Albiza - agonists
Morning glories / LSA - agonist
Argyreia Nervosa / LSA - agonist
Shroom / Psilocybin - agonist
Achuma / Mescaline - agonist
Yopo / Bufotenin- agonist
Cumala / DMT - agonist
Mimosa Hostilis/ DMT - agonist
Acacia confusa / DMT - agonist
Psychtria Viridis / DMT - agonist
D. huaorani / DMT - agonist
Feverfew - antagonist
Peppermint / Menthol - Antagonist
Indian snakeroot - Antagonist
___________________
#OPIOIDERGIC#
R. Rosea - ORI
Vitex - ORI
Opium poppy - agonist
Kratom - agonist
Akuamma - agonist
Sakae naa - agonist
Mitragyna Hirsuta - agonist
Mitragyna Javanica - agonist
Jamaican dogwood - agonist
iboga - k agonist
Salvia divatorum - k agonist
Psychotria Colorata - k agonist
Becche - k agonist
Voacanga Africans - k agonist
Jupiter sage - k agonist
Salvia recognia - k agonist
Cats claw - k agonst
Calycodendron milnei - k agonist
Purple prairie clover - Antagonist
Forskolin - k Antagonist
_______________________
#ADRENERGIC#
Tyramine - BB
NMT:N-methyltyramine - BB
Hordenine
Phenylethylamine - BB
Synephrine - BB
Octopamine - BB
DMBA
DMAA
DMAE
Bitter orange - BB
Coca / cocaine - SNDRI
Khat - cathinone - SNRI
Catuba / catuabine - NDRI
Yohimbe / Yohimbine - NDRI
S. Cordifolia / ephedrine - agonist
Ephedra / ephedrine - agonist
Eria Jarensis / N,N-DMPEA agonist
Coffee arabica / Caffine - agonist
Theacrine - agonist
Theobromine - agonist
Theanine - agonist
Theophylline - agonist
Methylliberine - agonist
Propylhexedrine - agonist
Levmetamfetamine - agonist
Epinephrine - agonist
Methylphenidate - NDRI
Adderall - NDRI/ NDRA
Potassium - antagonist
arginine - antagonist
rauwolfia serpentina - antagonist
Berberis vulgatis- antagonist
Magnesium - antagonist
_________________
#CHOLINERGIC#
Building Blocks
Phosphatidy serine
NAC
aGPC
Citicoline
Sarcosine
Taurine
Uridine phosphate
* CRI choline reuptake inhibitor*
Snowdrop /Galantamine - CRI
H. serrata / Huperzine A - CRI
Vinca Minor / vincamine - CRI
Polygala Tenifolia - CRI
Corydalis yanhusuo - CRI
Scotch Broom / Cytisine - agonist
Tobacco / Nicotine - agonist
Mescalbean /Cytisine - agonist
Lobelia Inflata / Lobeline - agonist
Areca Catechu / Arecoline - agonist
Tobacco / nicotine - agonist
Intellect Tree
Bacopa Monnieri
Nebracetam -  agonist
Colouracetam - CRI
phenylpiracetam - CRI /NDRI
BIIB-104 - AMPA Pam / GRI
Chamomile - Antagonist
Datura - Antagonist
Mandrake - Antagonist
Henbane - Antagonist
Nightshade - Antagonist
Labrador tea - Antagonist
Mad honey - Antagonist
Nutmeg - Antagonist
----
Methylphenylpiracetam - positive allosteric modulator of the sigma-1 receptor.
nefiracetam - gabaA agonist
Dimiracetam - relief of neuropathic pain
Seletracetam - SV2A agonist
Levetiracetam - SV2A agonist

_______________
#GLUTAMATERGIC#

AMPA
Glutamate – endogenous agonist
L-Theanine - glutamate reuptake inhibitor
Amanita muscaria / Ibotenic acid - agonist
Quisqualic acid – agonist
Willardiine – agonist
Cordycepts - AMPA Pam
Maitake - AMPA Pam
Noopept - AMPA Pam/ CRI
Aniracetam- AMPA Pam
Pramiracetam- AMPA Pam
Piracetam- AMPA Pam/ calcium channel blocker
Oxiracetam - AMPA Pam/ CRI
Pepa - AMPA Pam /GRI
Fasoracetam - AMPA Pam
Gabapentin - calcium channel blocker
Levetiracetam - calcium channel blocker

Glycine
Sarcosine - glycine reuptake inhibitor
Taurine - glycine reuptake inhibitor
Serine - glycine agonist
Uridine Monophosphate
BIIB-104 GRI

NMDA
Glutamate - agonist
D-Serine - agonist
Dehydroepiandrosterone/ DHEA - agonist
Xenon - Antagonist
Nitrous oxide - Antagonist
Magnesium glycinate - Antagonist
Dextromethorphan (DXM) - Antagonist
Sophora flavencences - Antagonist
Psychotria colorata - Antagonist



--------
#ADENOSINE#
Cordycepts - agonist
inosine - agonist
Incarvillea sinensis - agonist
Lactuca virosa - agonist
Calcium channel blockers AdRI
Benzodiazepines - AdRI
Progesterone DHEA - AdRI
Tricyclic antidepressants - AdRI
Caffeine - Antagonist
theophylline - Antagonist
theobromine - Antagonist
_________________
#CANNABINERGIC
Cannabis
Liverwort
black pepper - CBRI
Coneflower – Echinacea
Oxeye - Heliopsis helianthoides
Electric daisy
Helichrysum umbraculigerum
Palmitoylethanolamine - CBRI
_________________
#GABAergic#
Rubidium Bromide
GABA - BB
Thyme - GRI
Cloves - GRI
Skullcap - GRI
St John's wort - GRI
Ashwaganda - GRI
GABOB - agonist
Kava - agonist
Damiana - agonist
Valarian root - agonist
Mulungu - agonist
Magnolia - agonist
Albiza - agonist
Indian warrior - agonist
Amanita muscaria - agonist
Areca catechu - agonist
Phenibut - agonist
Wild dagga
Mugwort - antagonist
Kudzu - antagonist
Muira puma - antagonist
__________________
#MAOI#
Nutmeg
Ayahuasca vine
Passion flower
Syrian Rue
Grape fruit
Licorice
Black pepper
Tumeric
R. Rosea
Yohimbine
Tobacco
Kava
Olives
Betel nut
--------------------
P450 inhibitor
St johns wort
Starfruit
Goldenseal
Water Crest
____________________
#Other Analgesic#
Rhodiola rosea -Endorphin releasing agent and MAOI
Sakae Naa
Jewel vine
Incarvillea sinesis
Snapdragon root
Sophora genus
Corydalis
Scullcap
Pukatea
Chuchuhuasi
Lettuce opium
Devil's backbone
White Willow
Cats Claw
yellow horned poppy
_________________
#Other Sedative

Silene capensis
_________________
#Other Stimulant
Contrayerba
Goldenseal
Bitter orange
_________________
#Unknown
Rhodiola Crenulata
Wild dagga
Coleus
Galangal
Horse Chestnut
Zornia latifolia
Calamus
Mulungu
Sun Opener
Calea Dream Herb
African dream root
African dream herb
Sugandi dream root

Heat receptor
Cayenne peppers/Capsaicin

Cold receptor
Peppermint /Menthol

Pain receptor (topical)
Benzocaine
Lidocaine
Arnica
Cloves
Electric dasiy (toothache plant)

_________
__Ginseng__
Peruvian - Maca
Indian - Ashwaganda
Female - Angelica sinensis / dong quai
Malaysian - Tongkat ali
Brazilian - Suma
Alaskan - Devil's club
Siberian- Eleuthero
--------
__Steroid phytoandrogen__
DHEA
HMB
Horny goat weed
Tribulus terrestris
Wild yam
Eucommia ulmoides
Galangal
_______

Blood vessel dilator (NO)
Beets
Niacin
Beta alanine
Arginine
Agmatine
________

Blood sugar
thiamine
B complex
Niacin
Creatine
Berberine
Gymnema Sylvestre
-------
Pain relief
Adenosine
Opioid
Dopamine
Norephedrine
Sertonin
COX-2
Glutamate antagonist (NMDA antagonist)

Smarts
AMPA
Glycine
Acetylcholine
Dopamine/Norephedrine
Serotonin

Energy
Norephedrine/dopamine
Glutamate/Acetylcholine


Relaxant
Cannabidiol
Gaba
Opioid
Adenosine
Dopamine
Serotonin/melatonin

Category:Receptor_agonists
https://en.m.wikipedia.org/wiki/Category:Receptor_agonists

Category:Drugs_by_psychological_effects
https://en.m.wikipedia.org/wiki/Category:Drugs_by_psychologi...

[Edited on 11-3-2021 by symboom]
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XeonTheMGPony
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[*] posted on 11-3-2021 at 03:25


Quote: Originally posted by symboom  

Thank you that's great to hear.
akuamma is normally used as the replacement of kratom In places where it is illegal it is very similar herb that is from Africa unlike Kratom which is from Asia. They are very similar in that they are both partial opioids.
I put a lot of effort in this thread I was frustrated that there is so little research being done on these plants due to synthetic equivalent compounds already existing but now researches are discovering that there are better and safer alternatives from nature
So little information is found about many of the herbs I think it has to do with cost if a pharma company need to make a compound it is made syntheticly rather than extracted
Here is the research on kratom compounds and why a future synthetic partial opioid based on the structure kratom is being considered.
(Synthetic because a plant can't be patented)
https://pubs.acs.org/doi/10.1021/jacs.6b00360

MGM-9 kratom synthetic analog
https://www.sciencedirect.com/science/article/abs/pii/S00283...
And other MGM compounds
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067406/


Hodgkinsine is unfortunately hard to find a lot of information about.

[Edited on 5-1-2021 by symboom]

[Edited on 6-1-2021 by symboom]


well it has more to do with variation in dosage and potency, it is difficult to get a accurate clinical does with a plant as nature feels no need to abide by our dosing measures, one way to compensate is to make large batch, titrate the dose, then use that batch at established dose.

Then be sure to prepare the next batch and do the same in advance befor the first runs out, with purified extracts that been concentrated this extra labor and testing becomes irrelevant as you know the exact amount of compound per dose.

and by just making the compound you skip the rest of the cultivation step and then extraction steps.

Good knowledge to have indeed as humans seem to be getting dumber as a whole I'd prefer to take care of my own medical needs and any system that says I can't will get helpful suggestions of where I will place my boot!
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symboom
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[*] posted on 7-5-2021 at 23:09


IMG_20210320_153814748.jpg - 2MB IMG_20210329_175535617.jpg - 1.8MB


I think this was interesting and it is related to neuro chemistry

Neurochemical effects on the body

Opioid
Pain relief
Diarrhea relief
Appetite suppressant
Supposingly Cough relief
Can cause nausea
Overdose
Shortness of breath
--------------
Serotonin
Pain relief
Dry mouth
Cause weight loss
Laxative
Excessive Yawning
--improves mood

Overdose
Shortness of breath (serotonin syndrome)

Blocking serotonin
Increases body temperature
induce sleep
Antiemetic
Gains weight
---------------
Dopamine
Wakefulness promoting
Decreased appetite
Treats Parkinson’s disease
Treats hyperprolactinemia
restless legs syndrome relief
Raises sex drive
Can cause neasea
--motivation
--concentration


Blocking dopamine
induce sleep
Antiemetic
--------------

Norephedrine
Dry mouth
Bronchodilation
increases heart rate and force
constricts blood vessels
treating septic shock
Raise of adrenaline blocks histamine production
--motivation

Blocking Norephedrine
induce sleep
------
GABA
antiemetics
Pain relief
induce sleep
Lowers heart rate and force
--slows down thinking
--------
Acetylcholine
Laxative
Increases salivation
Excessive Yawning
Responsible for rest and aids digestion
contracts smooth muscles, dilates blood vessels, increases bodily secretions, and slows heart rate


Anticholinergics
Causes dry mouth
antiemetics
Bronchodilation
anticholinergics can reduce the acetylcholine-induced inflammatory response
--memory
-------

Histamine
Premotes wakefulness
Vasodilation and lowers blood pressure
Affects mucus membrane
Gastric acid release
Body temperature
Endocrine
Pain

Antihistamine
Antiemetic
Used as an antiacid (decreases production of stomach acid)
Promotes sleep
Causes weight gain(lowers thermogenesis)
antihistamine that can affect urination. It does so not by affecting the prostate, but by reducing the bladder's ability to contract.
------
Cannabinoids
Pain relief
antiemetics
Premotes sleep
--------
Other receptors

Adenosine
Treats supraventricular tachycardia
anti-inflammatory or immunosuppressive

tachykinin receptor
NK-1 antagonists boost the efficacy of 5-HT3 antagonists
-----------

bronchodilating drugs are β2("beta two")-adrenergic agonists (short- and long-acting), anticholinergics (short- and long-acting), and theophylline (long-acting).
----------
Relation to other neuroreceptors

--Raising serotonin decreases production of dopamine.

--blocking histamine can also block Acetylcholine production

--Acetylcholine can increase dopamine levels

--Histamine causes an increase in glutamate release
NMDA receptor (Glutamate) antagonists increase the serotonin levels in the brain

-- The dopamine-releasing effect of glutamate is mediated by AMPA (rather than NMDA) receptors.

---- Rasing Norephedrine decreases production of histamine
The body cannot handle large amounts of histamine. As a result, the body will counter-act histamine by producing Epinephrine (adrenaline) which helps to de-activate histamine. Sometimes high levels of adrenaline can result in unwanted anxiety and panic attacks.
------------
Agonst vs antagonist
Antagonist increase a receptors production making more of them agonist decrease a receptors production.
An agonist can be twice as strong if an antagonist is used first
Allowing the agonist to have more receptors for the agonist to bind too. This is used in pain clinics to lower dosage and tolerance in the patient.

Antagonist can also the block the action of an agonist from binding

Reuptake inhibitors can block an agonist because the Neurochemical is in the way for the agonist to bind to it.

This video shows alot of about Neurochemical
https://youtu.be/S-NukJp_Nbs
------
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin


---------
==================
A bit of topic
The connection between the body and brain actually go both ways

Psychological states

Psychogenic illness/Conversion disorder

Symptoms
Numbness, weakness, paralysis, seizures, tremor, fainting, impaired hearing, swallowing and vision.

Impaired coordination or balance
Weakness/paralysis of a limb or the entire body (hysterical paralysis or motor conversion disorders)
Impairment or loss of speech (hysterical aphonia)
Difficulty swallowing (dysphagia) or a sensation of a lump in the throat
Urinary retention
Psychogenic non-epileptic seizures or convulsions
Persistent dystonia
Tremor, myoclonus or other movement disorders
Gait problems (astasia-abasia)
Loss of consciousness (fainting)
Sensory symptoms or deficits:

Impaired vision (hysterical blindness), double vision
Impaired hearing (deafness)
Loss or disturbance of touch or pain sensation
--------------

physical symptoms of depression
-Psychogenic pain - common in severe depression a physical sensation of pain originating from the depression.

physical symptoms of anxiety

-psychogenic amnesia - memory loss due to anxiety

-Psychogenic heart attack - originate from the extreme form of a panic attack
psychogenic seizure - originate from the extreme form of a panic attack
-Psychogenic tremor - originate from the extreme form of a panic attack





[Edited on 8-5-2021 by symboom]




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[*] posted on 9-5-2021 at 18:35


This is absolutetly impressive. I would like to learn more about the methods you use for extraction, preservation and handling of your plant materials. I am extremely interested in this subject because we are restoring an old citrus orchard in the tropics and the array of diversity is incredible, more so when you consider that even the tiniest weed can rid you of worms or contain otherwise interesting components.
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symboom
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[*] posted on 9-5-2021 at 20:41


Here is a list of natural nmda antagonists
http://www.sciencemadness.org/talk/viewthread.php?tid=155429


Here are a list of natural antidepressants https://youtu.be/9nt67gj43ug


I try to keep things sterile I've havnt done any extraction of pure compounds been too busy. I've just made solution of the herb by using an ultrasonic bath and some everclear
I have a small 30W dehumidifier and try to save the silica gel packs I try to keep a sterile environment. Mold is aggressive in humid environments. I found that alot of this information was scattered around so I tried to compile it from scientific papers which paywalls are a real pain.

[Edited on 10-5-2021 by symboom]

[Edited on 11-5-2021 by symboom]
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