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Author: Subject: Nucleic acid synthesis
polymer
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[*] posted on 3-5-2007 at 13:28
Nucleic acid synthesis


For a while, I have been wanting to synthesize some DNA bases (Adenine, Guanine, Thymine, Uracil). Can you please suggest a few methods for going about this?

I meant Adenine, guanine, thymine, Cytosine. For some reason, I thought Uracil was a DNA base for a second

[Edited on 3-5-2007 by polymer]




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vulture
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[*] posted on 3-5-2007 at 13:52


Adenine is possible from HCN and NH3 only. Just need alot of patience.



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Sauron
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[*] posted on 3-5-2007 at 13:57


I think you mean uridine rather than uracil. Uracil is not a nucleoside; uridine is.
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[*] posted on 4-5-2007 at 09:42


These are the classic syntheses of DNA bases:

DNA bases1.bmp - 964kB
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[*] posted on 4-5-2007 at 09:52


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[*] posted on 4-5-2007 at 10:01


Sorry, the image seems to be quite big (900 kb or so).
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jtkelectroman
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[*] posted on 4-5-2007 at 11:21


Quote:
Originally posted by vulture
Adenine is possible from HCN and NH3 only. Just need alot of patience.

I beleive I have a somewhat detailed synthesis of this in a book of mine. The synthesis deals with ring formation from HCN and NH3
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