Khusimol

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Khusimol
Names
IUPAC name
[(1R,2S,5S,8R)-7,7-dimethyl-6-methylidene-2-tricyclo[6.2.1.01,5]undecanyl]methanol
Other names
Khusenol
Properties
C15H24O
Molar mass 220.356 g/mol
Appearance Oily liquid
Density 0.974 g/cm2[1]
Boiling point 150 °C (302 °F; 423 K) (at 0.02 mmHg)[2]
Immiscible
Solubility Soluble with organic solvents
Vapor pressure ~o mmHg
Hazards
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Khusimol is a sesquiterpene found in the essential oil of vetiver (Chrysopogon zizanioides). It contains a tricyclic hydrocarbon core, with a hydroxy methyl group, two methyl groups and a methylene group. It constitutes the biggest part of oil of vetiver, around 15%.

Properties

Chemical

As it contains a primary alcohol, khusimol can be oxidized with the Jones reagent to its respective carboxylic acid.

Physical

Khusimol is an oily liquid, immiscible with water, bus soluble in organic solvents.

Availability

Khusimol can be extracted from the essential oil of vetiver plant. Methanol is often used as the choice solvent. The essential oil contains around 15% khusimol by weight.[3][4]

Preparation

It's better to extract it and purify it from the essential oil of vetiver plant.

Projects

  • Compound collecting
  • Make esters
  • Make anti-fungal agent
  • Treat acne and sores

Handling

Safety

There is little data available about khusimol's toxicity.

Storage

Should be kept in closed airtight bottles, away from air an light.

Disposal

No special disposal is required. Can be diluted with water and poured down the drain.

References

  1. Nigam; Radecka; Komae; Journal of Pharmaceutical Sciences; vol. 57; nb. 6; (1968); p. 1029 - 1030
  2. Takahashi,S.; Chemical and pharmaceutical bulletin; vol. 16; (1968); p. 2447 - 2450
  3. https://www.sciencedirect.com/science/article/abs/pii/S0040403901997047?via%3Dihub
  4. https://pubs.acs.org/doi/abs/10.1021/np50112a001

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