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Toxicity of AChE Inhibitors on a Quantitative, Molecular level
[quote]...explain why, for example, Soman has a lower LD50 than Sarin when the two molecules are ext ...
14-10-2009 at 07:36
by: PainKilla
Why are atoms in constant motion?
From a historical perspective, atoms are in constant motion because of the success of Newtonian law: ...
13-10-2009 at 22:11
by: PainKilla
Toxicity of AChE Inhibitors on a Quantitative, Molecular level
The biggest problem with using MD is that without specific manipulation you can only hope that the ' ...
13-10-2009 at 21:44
by: PainKilla
Toxicity of AChE Inhibitors on a Quantitative, Molecular level
I'm not particularly familiar with the topic, although I did glance at the papers and the 1VXR PDB s ...
13-10-2009 at 19:28
by: PainKilla
Adios
I'd like to add my views on the state/evolution of MSDB, if you will...

When I joined in 2004, I ...
10-7-2009 at 10:55
by: PainKilla
When does an electron have kinetic energy as opposed to potential energy?
If you are approaching Bohr's model, you need to understand the underlying physical principles and a ...
29-6-2009 at 15:52
by: PainKilla
Iodomethane prep.
Thanks, it's nice to see some real data finally!

I personally don't like negative pKa's at all, ...
26-6-2009 at 03:24
by: PainKilla
Iodomethane prep.
Oh, I certainly agree, considering the paper I posted before that suggested reactions occured even i ...
26-6-2009 at 00:57
by: PainKilla
Iodomethane prep.
I only needed MeI/DMS for methylations, and not on any particularly deactivated substrate either - m ...
25-6-2009 at 11:49
by: PainKilla
Iodomethane prep.
I don't think you even need (anhydrous) methylsulfuric acid for this reaction, as Antoncho demonstra ...
25-6-2009 at 11:11
by: PainKilla
Iodomethane prep.
Yeah, what's what I figured you meant, I just wanted to see if I could find any mention towards the ...
25-6-2009 at 10:54
by: PainKilla
Iodomethane prep.
I don't know much about the chemistry of that anion but:

http://books.google.com/books?id=zBpJAAA ...
25-6-2009 at 00:40
by: PainKilla
Iodomethane prep.
That's 230ml or 525g @ 62% (methyl iodide has a density of 2.28g/ml) for a kilogram of potassium iod ...
24-6-2009 at 23:04
by: PainKilla
Iodomethane prep.
The reaction occurs pretty much instantly, and at relatively high temperatures with a concentrated i ...
24-6-2009 at 22:04
by: PainKilla
Iodomethane prep.
Based on the rates of hydrolysis, methylsulfuric acid is probably as dangerous as sulfuric acid, but ...
24-6-2009 at 20:50
by: PainKilla
Iodomethane prep.
You can make methyl iodide quite easily and in good yield by slowly adding methylsulfuric acid to a ...
24-6-2009 at 18:24
by: PainKilla
Methylation of phenols with Methyl Nitrate
Yes, thin white/clear flaks are the best way to describe it. However it should be noted that 1,4-dim ...
18-3-2009 at 17:34
by: PainKilla
Methylation of phenols with Methyl Nitrate
I would recommend a workup in which you just dump your reaction mixture into cold water, make it alk ...
18-3-2009 at 16:03
by: PainKilla
Allstar Lab?
That seems pretty unlikely to me. You are more likely to get cyclization after one round of Sn2 (THF ...
13-3-2009 at 18:33
by: PainKilla
methylenedioxybenzyl chloride + sommelet?
One more, can post more on chloro/bromomethylation if it's needed, but this covers a lot.
2-10-2008 at 02:23
by: PainKilla
methylenedioxybenzyl chloride + sommelet?
Attached.
2-10-2008 at 02:21
by: PainKilla
methylenedioxybenzyl chloride + sommelet?
Attached.
2-10-2008 at 02:18
by: PainKilla
methylenedioxybenzyl chloride + sommelet?
Attached.
2-10-2008 at 02:17
by: PainKilla
Safe or Stupid?
[quote][i]Originally posted by blogfast25[/i]
Most people that know that hot stoves (or chemicals) ...
23-9-2008 at 14:35
by: PainKilla
Safe or Stupid?
I think you'd be hard-pressed to find an 8-year old that can write up a scientific experiment... I a ...
23-9-2008 at 05:14
by: PainKilla
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