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5-MeO-DIPT Synthesis from melatonin
You'd need a base like N,N-diisopropylethylamine or triethylamine to prevent formation of the quater ...
28-12-2016 at 23:38
by: Rich_Insane
Issues with working up a Beckmann-rearrangement type reaction
The purpose of this experiment is to try out various divalent metal salts to rearrange the oxime to ...
20-9-2015 at 11:08
by: Rich_Insane
Issues with working up a Beckmann-rearrangement type reaction
Hey everyone,

So I've posted about amide synthesis a lot. I have run a reaction in which an oxime ...
18-9-2015 at 14:31
by: Rich_Insane
Tryptamine synthesis: workup woes
I am using this paper as a reference: "Chemistry Letters 893-896 (1986)"

My goal was to replicate ...
15-7-2015 at 13:24
by: Rich_Insane
Organic halides with piperdine
I'm planning a reaction of a substrate with piperidine:

[img]http://i.imgur.com/flTXrBy.png[/img] ...
23-12-2014 at 20:49
by: Rich_Insane
Synthesis of amino acid chlorides
I like the Fmoc group because deprotection is fairly simple with DBU or piperidine. However, I have ...
31-7-2014 at 01:20
by: Rich_Insane
Properties of diphenhydramine base?
Use DCM to isolate the base and then wash the organic layer with water. Remove the DCM under reduced ...
17-7-2014 at 14:29
by: Rich_Insane
Selling many supplies and chemicals
I actually live in Portland! Could you U2U me a list of what is available? There are a few reagents ...
17-7-2014 at 10:41
by: Rich_Insane
Calculating purity
Yea, I'd say comparing to the standard is the best idea. I could use DAD area @ 254 nm or use our UV ...
6-2-2014 at 11:44
by: Rich_Insane
Calculating purity
I am not sure what software I am using. It came with our TOF-LCMS system (Agilent). I use the "Quali ...
4-2-2014 at 22:08
by: Rich_Insane
Prototocatechualdehyde methylenation. Photo-essay.
Pardon me if this question is a bit tangential, but do you think that the high temperature (hence wh ...
4-2-2014 at 14:08
by: Rich_Insane
Calculating purity
Hey everyone,

So I'm a little confused as to how purity is calculated for novel compounds. Let's ...
4-2-2014 at 13:53
by: Rich_Insane
Oximes
Here is a procedure from OrgSyn: [url=http://www.orgsyn.org/Content/pdfs/procedures/cv2p0622.pdf]Ver ...
24-1-2014 at 15:36
by: Rich_Insane
Pressing issue and a question
Hey everyone.

I am working with construction of (non-peptide) oligomers at work. The SPS resin I ...
22-1-2014 at 15:13
by: Rich_Insane
Hunig's base
As far as solubility, I've used DIEA regularly for peptide synthesis. The DIEA easily goes into solu ...
25-12-2013 at 14:30
by: Rich_Insane
Why did you get into Chemistry?
I was very (obsessively) interested with rocks and minerals as a kid, and that lead me to try to und ...
27-11-2013 at 11:51
by: Rich_Insane
Trimethoxy-Cathinone
This compound would most likely not be all that active. I don't think substitution in the beta posit ...
27-11-2013 at 11:14
by: Rich_Insane
Revisit to Zealot's total synthesis of Ketamine
Would there be any reason why something like dry ethylene glycol would be undesirable?

Also, try ...
18-10-2013 at 21:09
by: Rich_Insane
Revisit to Zealot's total synthesis of Ketamine
1/2. The benzamide is synthesized from the carboxylic acid. The first reaction involves diazonium sa ...
14-10-2013 at 21:32
by: Rich_Insane
Revisit to Zealot's total synthesis of Ketamine
Please provide a source/reference.


[quote]
I'm not an expert but aren't o-Bromobenzoic Acid a ...
6-10-2013 at 19:57
by: Rich_Insane
Cancer Cure
Regarding the effectiveness of cannabinoids in treating certain types of cancer:

1) "Cancer Res, ...
28-9-2013 at 10:29
by: Rich_Insane
Using N-bromosuccinimide to synthesize acyl bromides or carboxamides

[quote]
Anyway, the electrophilicity of NBS is modulated by the polarity and acidity of the media ...
28-9-2013 at 10:17
by: Rich_Insane
MAOI(harmine) extraction of tobacco
If I recall correctly, the Pictet-Spengler (probably misspelled) cyclization reaction is quite strai ...
27-9-2013 at 18:17
by: Rich_Insane
Using N-bromosuccinimide to synthesize acyl bromides or carboxamides

[quote]
Volume of what? When you cite, make sure you really do.[/quote]


Oops, my bad, it's f ...
27-9-2013 at 18:13
by: Rich_Insane
Using N-bromosuccinimide to synthesize acyl bromides or carboxamides
I've seen that reference somewhere, but I'm interested in a route that gives direct access to an ami ...
27-9-2013 at 08:40
by: Rich_Insane
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