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Author: Subject: Oxo to Hydroxy (C=O to CH-OH) Reduction
kamal
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thumbup.gif posted on 17-8-2006 at 06:21
Oxo to Hydroxy (C=O to CH-OH) Reduction


Hi to all...!!!!

I'm trying to get :

Ethyl-4-Bromo-3-Hydroxy butyrate from Ethyl-4-Bromo-3-Oxo-Butyrate.

I tried searching beilstein, orgsyn, etc. but not getting proper process for this. Only one with Sucrose & yeast as per orgsyn was there but is very long & lazy process.....

May I get suggetions from you friends for this C=O to CH-OH reduction.....?
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[*] posted on 17-8-2006 at 06:54


Try "Organic Reaction V2", the Meerwein-Ponndorf-Verley Reduction. There is a subsection on alpha-bromo-ketones.
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kamal
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[*] posted on 19-8-2006 at 21:04
Ref. papers


Do you have exact ref. journal paper suggetions for this ?
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[*] posted on 19-8-2006 at 22:17


http://www.sciencemadness.org/library/index.html

Get Org Reactions V2, read the chapter; there's a slew of references although only a few for your specific case.


But if you must, or can't figure out how to download, try starting here:

http://people.bu.edu/jaylowe/Named%20reactions/M/MPV/meerwei...

R. M. Kellogg, Comp. Org. Syn. 8, 88-91 (1991)
C. F. de Graauw et al., Synthesis 10, 1007-1017 (1994).
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kamal
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[*] posted on 19-8-2006 at 23:02
Thanks!


Thanks dear !

I'm now collecting these ref. from our library......
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