HollowMan
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N,N-Dimethylamphetamine byproduct
Hello,
I just read some articles on erowid about the illicit synthesis of amphetamine/methamphetamine and the occurring byproducts.
I was wondering, how N,N-dimethylamphetamine can arise during a P2P reductive amination process.
Does anyone of you can tell me the way how the dimethylation works?
If u just have P2P, MeNH2, MeOH, NaOH und AlHg as a starting material I can´t explain it to me.
Thanks so far
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UC235
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People use shitty impure methylamine made from hexamine. Recrystallization is needed to remove all of the dimethylammonium chloride and ammonium
chloride.
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HollowMan
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Quote: Originally posted by UC235  | | People use shitty impure methylamine made from hexamine. Recrystallization is needed to remove all of the dimethylammonium chloride and ammonium
chloride. |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662403/table/t...
I don´t think they used shitty impure methylamine in this experiment. But of course the amount is also really low...
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tsathoggua1
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Wouldn't worry too much about low levels of N,N-dimethylamphetamine. Its known to be an active stimulant, although much weaker than the secondary or
primary amine counterparts. With the phenethylamine world, a tert. amine generally leads to lesser activity either in the case of N-methylated
amphetamines, with the main exceptions of methylenedioxy ring substitution and ring-alkoxylated methlyenedioxyphenylaminopropenes. And the simple
stimulants, N-alkylamphetamines retain activity, but it lowers as the chain length increases, IIRC N-(iso)propylamphetamine is something like a
quarter of the potency of plain amphetamine. N-ethyl seems to be about the sweet spot, its not as weight-potent as meth but very smooth stuff.
A tertiary amine however, both for stimulants and psychedelic phenethylamine/amphetamine 5HT2a agonists doesn't seem to be tolerated, it is to a
degree with the simple stimulants but usually results in a dramatic loss of psychedelic activity.
Although, in the case of cyclized indane derivatives the N-methylated derivative of 2-aminoindan is active and I'd say stronger than 2-aminoindan.
Both are, however, mediocre at best in my estimation, having a fair degree of peripheral adrenergic type activity. Bit rough, not hideously so but
still, I didn't consider it worth repeating.
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Texium
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Thread Moved
27-11-2023 at 11:32 |
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