SunriseSunset
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Cross-Coupling of Aryl Halides with Alkyl Halides?
Does anybody know by chance what conditions/reagents/catalysts could be applied in performing this kind of reaction?
But without using pyridine?! The closest that I've come to at least having a name to use for searching is Coupling of Aryl Halides with Alkyl Halides
except so far everything uses pyridine 
Why do chemists call helium, curium and barium the medical elements?
because if you cant helium or curium, you barium! - Heimerdinger
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Metacelsus
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https://en.wikipedia.org/wiki/Kumada_coupling
Uses palladium or nickel catalysts, couples aryl or vinyl Grignard reagent (made from Mg and halide) to halide.
https://en.wikipedia.org/wiki/Heck_reaction
Couples aryl/vinyl halides with alkenes, using palladium catalysts (alkenes can then be hydrogenated if you want alkanes).
The palladium catalysts can be feasibly prepared from palladium metal, but are not cheap.
[Edited on 25-9-2015 by Cheddite Cheese]
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Crowfjord
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Similarly, there are many ways to use copper catalysts to couple alkyl or aryl Grignard reagents with alkyl or aryl halides. There are a lot of
references on the web if you search. I have a particular one in mind, but can't find it right now. Will post it later when I find it.
........
Here's the one I was thinking of. The paper describes alkylation of grignards, catalyzed by copper (II) chloride and lithium chloride, with or without
NMP cosolvent.
[Edited on 26-9-2015 by Crowfjord]
Attachment: Cu-Catalyzed Alkylation of Grignard Reagents.pdf (335kB)
This file has been downloaded 1413 times
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Nicodem
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Thread Moved
24-9-2015 at 21:31 |
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