Interesting mono- or di-substituted pyridine synthesis
Just stumbled across this paper, which seems to be almost amateur friendly, and provides an easy route to 2- or 2,3-substituted pyridines.
ABSTRACT: A copper-catalyzed reaction providing direct access to 2-
arylpyridines from acetophenones and 1,3-diaminopropane is described. A
range of electronically diverse acetophenones undergo this transformation,
affording 2-arylpyridines in good yields.
Attachment: ol5023596.pdf (308kB)
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The picture abstract shows 1-hexanol as solvent, but their rxn optimisation indicates that ethanol is also a suitable solvent. It also shows
copper(II) triflate, but I wonder if copper p-toluenesulphate could also be used.
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