thors.lab
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Use of decyltriethylammonium iodide in ether synthesis in PiHKAL?
In PiHKAL #30 and #37 (and probably others, I was just flipping through randomly), Sasha uses what I believe to be the Williamson ether synthesis to
alkylate the alcohol groups on the ring forming the ethers.
He adds, for example, 3,6-dihydroxybenzonorbornane with K2CO3 as the base and methyl iodide in acetone to form the 3,6-dimethoxybenzonorbornane.
However, he also adds a small amount of decyltriethylammonium iodide to the reaction. Why is this there? What purpose does this serve?
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Metacelsus
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Hmm, usually this is a phase transfer catalyst. Maybe this helps dissolve the K2CO3 in the organic phase?
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thors.lab
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Neat, thanks!
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