The WiZard is In
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Time to stock up on brodifacoum, bromadiolone, difethialone and difenacoum
EPA Takes Major Actions to Reduce Americans’ Risks from Mouse and
Rat Poisons / Move will better protect children, pets and wildlife
Release date: 06/07/2011
http://tinyurl.com/5sosmhz
djh
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8vi11
2 new elements officially added to periodic table
http://tinyurl.com/3msn9l4
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The WiZard is In
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I ran these past The Merck Index. Impressive LD50 for mice!
Monograph Number: 0001379
Title: Brodifacoum
CAS Registry Number: 56073-10-0
CAS Name: 3-[3-(4¢-Bromo[1,1¢-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzopyran-2-one
Additional Names: 3-[3-(4¢-bromobiphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]-4-hydroxycoumarin
Manufacturers' Codes: PP-581; WBA-8119
Trademarks: Talon (Zeneca Ag Prod)
Molecular Formula: C31H23BrO3
Molecular Weight: 523.42
Percent Composition: C 71.13%, H 4.43%, Br 15.27%, O 9.17%
Literature References: Coumarin analog. Prepn: M. R. Hadler, R. S. Shadbolt, DE 2424806; eidem, US 3957824 (1975, 1976 to Ward, Blenkinsop &
Co.); eidem; J. Chem. Soc. Perkin Trans. 1 1976, 1190. Anticoagulant activity: M. R. Hadler, R. S. Shadbolt, Nature 253, 275 (1975). Field trials:
B. D. Rennison, A. C. Dubock, J. Hyg. 80, 77 (1978); F. P. Rowe et al., ibid. 81, 197 (1978). Efficacy and toxicity: L. Yuet-Ming, Malays. Agric. J.
52, 1 (1980).
Properties: Off-white powder, mp 228-230°. Insol in water. Slightly sol in alc, benzene; sol in acetone, chloroform. LD50 orally in male, female
field rats: 0.16, 0.18 mg/kg (Yuet-Ming).
Melting point: mp 228-230°
Toxicity data: LD50 orally in male, female field rats: 0.16, 0.18 mg/kg (Yuet-Ming)
Use: Rodenticide.
Monograph Number: 0001382
Title: Bromadiolone
CAS Registry Number: 28772-56-7
CAS Name: 3-[3-(4¢-Bromo[1,1¢-biphenyl]-4-yl)-3-hydroxy-1-phenylpropyl]-4-hydroxy-2H-1-benzopyran-2-one
Additional Names: 3-[a-[p-(p-bromophenyl)-b-hydroxyphenethyl]benzyl]-4-hydroxycoumarin
Manufacturers' Codes: LM-637
Trademarks: Maki (Lipha); Bromone (Lipha); Super-Caid (Lipha); Super-Rozol (Lipha)
Molecular Formula: C30H23BrO4
Molecular Weight: 527.41
Percent Composition: C 68.32%, H 4.40%, Br 15.15%, O 12.13%
Literature References: Anticoagulant rodenticide. Prepn: E. Boschetti et al., DE 1959317; eidem, US 3764693 (1970, 1973 both to Lipha). Activity
studies: eidem, Chim. Ther. 7, 20 (1972); M. Grand, Phytiatr.-Phytopharm. 25, 69 (1976); R. E. Marsh, Bull. OEPP 7, 495 (1977); R. Redfern, J. E.
Gill, J. Hyg. 84, 263 (1980). Pharmacokinetics: K. Nahas, Pharmacol. Res. Commun. 19, 767 (1987). HPLC determn of diastereoisomers in animal
tissues: K. Hunter et al., J. Chromatogr. 435, 83 (1988).
Properties: White to offwhite powder, mp 200-210°. uv max (ethanol): 260 nm (E1%1cm 538-582). pKa (21°) 4.04. Soly at 20-25° (g/l):
dimethylformamide 730.0; ethyl acetate 25.0; acetone 22.3; chloroform 10.1; ethanol 8.2; methanol 5.6; ethyl ether 3.7; hexane 0.2; water 0.019. LD50
in rats, mice (mg/kg): 1.125, 1.75 orally (Grand).
Melting point: mp 200-210°
pKa: pKa (21°) 4.04
Absorption maximum: uv max (ethanol): 260 nm (E1%1cm 538-582)
Toxicity data: LD50 in rats, mice (mg/kg): 1.125, 1.75 orally (Grand)
Use: Rodenticide.
Monograph Number: 0003139
Title: Difethialone
CAS Registry Number: 104653-34-1
CAS Name: 3-[3-(4¢-Bromo[1,1¢-biphenyl]-4-yl)-1,2,3,4-tetrahydro-1-naphthalenyl]-4-hydroxy-2H-1-benzothiopyran-2-one
Manufacturers' Codes: LM-2219
Trademarks: Generation (LiphaTech); Hombre (LiphaTech)
Molecular Formula: C31H23BrO2S
Molecular Weight: 539.48
Percent Composition: C 69.02%, H 4.30%, Br 14.81%, O 5.93%, S 5.94%
Literature References: Second generation anticoagulant rodenticide; member of the hydroxy-4-benzothiopyranone family. Prepn: J.-J. Berthelon, FR
2562893; idem, US 4585786 (1985, 1986 both to Lipha). HPLC determn of residue levels in rats: D. A. Goldade et al., J. Agric. Food Chem. 46, 504
(1998). Use against warfarin-resistant rodents: K. Nahas et al., Anal. Rech. Vét. 20, 159 (1989). Toxicity in rodents and non-target species: J.
C. Lechevin, R. M. Poche, Proc. Vetebr. Pest Conf. 13, 59 (1988); S. Moran, Crop Prot. 12, 501 (1993). Laboratory and field studies: C. Sheikher, P.
Sood, Indian J. Agric. Sci. 70, 312 (2000). Use in conjunction with compounds to improve bait acceptance: H. Kaur, V. R. Parshad, Int. Pest Control
46, 88 (2004).
Properties: Prepd as a variable proportion of the (1RS,3RS) and (1RS,3SR) racemates, mp 203-227°. LD50 orally in male, female rats, mice (mg/kg):
0.62, 0.42, 0.52, 0.43 (non-resistant); 0.27, 0.39, 0.46, 0.52 (warfarin resistant). LD50 in hare: 0.75 mg/kg. LC50 in mallard duck, bobwhite quail
(ppm): 1.94, 0.56. LD50 at 48 hrs in daphnia magna, bluegill sunfish, rainbow trout (mg/l): 4.4, 110, 67 (Lechevin).
Melting point: mp 203-227°
Toxicity data: LD50 orally in male, female rats, mice (mg/kg): 0.62, 0.42, 0.52, 0.43 (non-resistant); 0.27, 0.39, 0.46, 0.52 (warfarin resistant);
LD50 in hare: 0.75 mg/kg; LC50 in mallard duck, bobwhite quail (ppm): 1.94, 0.56; LD50 at 48 hrs in daphnia magna, bluegill sunfish, rainbow trout
(mg/l): 4.4, 110, 67 (Lechevin)
Use: Pesticide.
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difenacoum dobe not found.
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The WiZard is In
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Found it.
Monograph Number: 0003133
Title: Difenacoum
CAS Registry Number: 56073-07-5
CAS Name: 3-(3-[1,1¢-Biphenyl]-4-yl-1,2,3,4-tetrahydro-1-naphthalenyl)-4-hydroxy-2H-1-benzopyran-2-one
Additional Names: 3-[3-(biphenyl-4-yl)-1,2,3,4-tetrahydro-1-naphthyl]-4-hydroxycoumarin;
3-(3-p-biphenyl-1,2,3,4-tetrahydronaphth-1-yl)-4-hydroxycoumarin
Trademarks: Neosorexa (Sorex); Ratak (Sorex)
Molecular Formula: C31H24O3
Molecular Weight: 444.52
Percent Composition: C 83.76%, H 5.44%, O 10.80%
Literature References: Second generation anticoagulant rodenticide. Prepn: M. R. Hadler, R. S. Shadbolt, DE 2424806; idem, US 3957824 (1975, 1976
both to Ward Blenkinsop); R. S. Shadbolt et al., J. Chem. Soc. Perkin Trans. 1 1976, 1190. Comprehensive description: J. O. Bull, Proc. Vertebr.
Pest Conf. 7, 72 (1976). HPLC determn of rat blood and liver: M. J. Kelly et al., J. Chromatogr. 620, 105 (1993); of residue levels in rats: H.
Atterby et al., Environ. Toxicol. Chem. 24, 318 (2005). Field and laboratory studies against the house mouse: F. P. Rowe et al., J. Hyg. Camb. 87,
171 (1981). Pharmacokinetics and pharmacodynamics in rabbits: A. M. Breckenridge et al., Br. J. Pharmacol. 84, 81 (1985). Pharmacological variation
between rodent sexes: M. J. Winn et al., J. Pharm. Pharmacol. 39, 219 (1987).
Properties: Crystals from ethyl acetate, mp 215-217°. LD50 orally in Wistar male, female rats (mg/kg): 1.8, 2.5; in male rabbits: 2.0 mg/kg; in
dogs: 50 mg/kg; in cats: 100 mg/kg (Bull).
Melting point: mp 215-217°
Toxicity data: LD50 orally in Wistar male, female rats (mg/kg): 1.8, 2.5; in male rabbits: 2.0 mg/kg; in dogs: 50 mg/kg; in cats: 100 mg/kg
Use: Pesticide.
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Ozone
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Yea, I actually had to post a Facebook update on this, another fine demonstration of reckless stupidity and lack of forsight on the behalf of the
EPA. Plague, anyone?
Of course, it is transparently political, as are almost all things that are "for the good of the children". Since when does the EPA have sanction over
Child-Welfare, anyway?
Ah, yes... IT has been this way since it was discovered that if you (read Washington) cannot accomplish what you want by legislating it (e.g. by vote)
then you can always regulate it (using a tool like the EPA). See Cap-and-Trade vs. EPA regulation of CO2 as a pollutant...
Gah, and we are forced to pay for this.
 O3
[Edited on 8-6-2011 by Ozone]
-Anyone who never made a mistake never tried anything new.
--Albert Einstein
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Ozone
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And...We are undoing centuries of evolution. The children of parents who allow them access to rodenticides will be preserved and they will be allowed
to reproduce.
-Anyone who never made a mistake never tried anything new.
--Albert Einstein
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The WiZard is In
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Quote: Originally posted by Ozone  |
Ah, yes... IT has been this way since it was discovered that if you (read Washington) cannot accomplish what you want by legislating it (e.g. by vote)
then you can always regulate it (using a tool like the EPA). See Cap-and-Trade vs. EPA regulation of CO2 as a pollutant...
Gah, and we are forced to pay for this.
O3 |
To quote myself — Liberals are people who believe everyone
is responsible for everyone else but no one is responsible for
themselves. That no matter what happens to you - it was someone
else fault. Only the Government knows how to protect
you, so don't take any responsibility for your own actions,the
Government is their role as Supper Momma will
promulgate regulations too protect you from having to
take any (personal/family) responsibilities.
This should keep them busy —
New Scientist
9 vi 01
EACH YEAR around this time Feedback's favourite government report
appears-the Home and Leisure Accident Surveillance System report from
Britain's Department of Trade and Industry. It gives figures for accidents reported
by people admitted to a sample group of British hospitals and then gives
extrapolated estimates for the country as a whole.
First the bad news in this year's report, which is based on 1999 data: the toll of
accidents caused by tea cosies is up again, with a national estimate of 37 tea
cosy injuries, compared with 20 the previous year. Equally alarming, the number
of accidents caused by place mats - a menace we have paid too little attention to
in the past-is up from 157 to 165 across the country as a whole.
These worrying figures are somewhat balanced by a welcome decline in
another area of concern-sponge and loofah accidents. The shocking previous
total of 996 nationwide is now down to 787.
But the major causes of concern are still with us. The number of people
hospitalised after a trouser accident (up from 5137 to 5945) is worryingly high,
while the drop in injuries inflicted by armchairs (down from 18,690 to 16,662)
leaves little room for complacency. Hospitalisations caused by socks and tights
have also risen (10,773 compared to 9843 previously), while injuries inflicted by
vegetables remain unacceptably high at 13,132 compared with the previous
year's 12,362.
The number of accidents involving tree trunks has also risen from 1777 to
1810, while leaf accidents have soared from 664 to 1171, with a similar increase
in birdbath accidents from 117 to 311.
Many people will also be shocked by the number of accidents caused by
beanbags, which has risen from 957 to 1317. The seriousness of this menace
becomes clear when measured against the 329 injuries caused by meat cleavers
or the 439 caused by rat or mouse poison.
In fact, the report makes it clearer than ever that our homes are full of
unacknowledged dangers. It identifies 3421 people nationwide as having been
injured by clothes baskets, while other threats include dust pans (146 injuries),
bread bins (91), talcum powder (73), toiletroll holders (329), clogs (622), false
teeth (933) and wellington boots (5615).
As in the past, printed magazines like New Scientist caused far
more injuries than chainsaws - 4371 compared with 1207.
djh
---
It is difficult to make our material
condition better by the best law,
but it is easy enough to ruin it by bad laws.
Theodore Roosevelt
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m1tanker78
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@TWII: Baby steps toward... heck, I won't even say it.
It's like an evil pet. It begins life as a cute puppy at your doorstep. You feed it, it grows, you feed it more, it grows more. At some point, it
stops begging and begins DEMANDING more food. It grows to such an enormous beast that you can't kick it out of the house or give it away to some
unsuspecting poor bastard. In the meantime, stray cats are invading your garden along with tent-pitching _______.
You're stuck with it and it will continue to eat and grow until you can no longer provide it with food. It will eat you, your house, and itself just
as it's offspring show up at your neighbors' doorsteps.
Sorry for ranting, It's extremely disturbing that my kids and someday, grandkids won't have the same privileges that I and my ancestors enjoyed in
this little piece of the globe. What's with the dog/cats and underlines? I'm not intentionally directing this at anyone or anything. Just ranting.
Tank
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Ozone
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Yes, on both counts. The EPA began as a good idea, and it accomplished a lot (which is why our environment is among the best in the world).
Unfortunately, the environment appears to be the last thing it is concerned with--which has shifted to using (Al Gore's voice) "the environment " to
leverage unrelated political ambition.
It, like the Dept. of Education* (see: http://www.google.com/gwt/x?u=http%3A%2F%2Fwww.news10.net%2F...) needs to go. Today.
Anyway, I attached my "clipping" from today's newspaper.
Cheers,
O3
*THIS is what they needed 27 short-barrelled shotguns for. They made us buy them.
[Edited on 8-6-2011 by Ozone]
-Anyone who never made a mistake never tried anything new.
--Albert Einstein
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