niertap
Hazard to Self
Posts: 76
Registered: 5-8-2011
Member Is Offline
Mood: hyper-conjucated
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Carboxylic acid reduction. Al/Hg , nickel cat.
Does anyone know if the Al/Hg reduction will work on a carboxylic acid/ mechanism behind it?
Or would a Raney nickel H2/ urushibara work on reducing it?
By mechanism I mean will it go directly to the alcohol or will the aldehyde ever be in solution in a meaningful concentration.
Ignorance is bliss
Outliers in life are modeled by chemical kinetics
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solo
International Hazard
Posts: 3967
Registered: 9-12-2002
Location: Estados Unidos de La Republica Mexicana
Member Is Offline
Mood: ....getting old and drowning in a sea of knowledge
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....have you tried a basic search here or in google?....do some reading and basic research before asking to be spoon fed...solo
case and point ....in google,
Mild Reduction of Carboxylic Acids to Alcohols Using Cyanuric
Chloride and Sodium Borohydride
Massimo Falorni,* Andrea Porcheddu and Maurizio Taddei
Tetrahedron Letters
1999, 40, 4395-4396
Abstract
Several carboxylic acids, including N-Boo, N-Cbz and N-Fmoe amino acids were reduced to the corresponding alcohols by activation
of the carboxy function with cyanuric chloride and N-methylmorpholine followed by reduction with aqueous sodium borohydride.
[Edited on 15-8-2011 by solo]
It's better to die on your feet, than live on your knees....Emiliano Zapata.
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