Sciencemadness Discussion Board
Not logged in [Login ]
Go To Bottom

Printable Version  
Author: Subject: Amino acids synthesis...
kazaa81
Hazard to Others
***




Posts: 368
Registered: 30-4-2004
Member Is Offline

Mood: ok

shocked.gif posted on 6-5-2006 at 09:07
Amino acids synthesis...


Hi,

I am searching for a way to synthetize amino acids...anyone can help?
Obviously short-chain amino acids would be easier to synth. than long-chain ones.
Glycine would be the easiest.

Another idea I have in mind is to synth. them by breaking the peptidic chains of keratin, hair-polymer.

In attachment there is a text file I compiled.

[Edited on 6-5-2006 by kazaa81]

Attachment: Aminoacids-by-kazaa81.txt (4kB)
This file has been downloaded 964 times

View user's profile View All Posts By User
nitroglycol
Hazard to Self
**




Posts: 56
Registered: 28-10-2005
Location: close to the centre of North America
Member Is Offline

Mood: curious

[*] posted on 6-5-2006 at 10:09


Just an off-the-cuff suggestion for glycine- start with diethyl malonate, add NaNH2, isolate the product, then saponify the ester and decarboxylate? I'm not sure how easily the decarboxylation would go, though, or if there are side reactions that would mess it up. I suppose if I had time I could look it up, but at least you know where to start.
View user's profile Visit user's homepage View All Posts By User
leu
Hazard to Others
***




Posts: 368
Registered: 13-10-2005
Member Is Offline

Mood: No Mood

[*] posted on 6-5-2006 at 16:30


A general method of synthesizing amino acids is by means of the Strecker reaction; from an aldehyde, a cyanide and ammonia. From:

http://chemistry2.csudh.edu/rpendarvis/aminoacids.html

The reaction begins with imine formation from an aldehyde and ammonia. The acid catalysis required for this comes from ammonium chloride, a weak acid. An addition of hydrogen cyanide to the imine follows. This is analogous to the additions of nucleophiles to an aldehyde or ketone which we studied earlier. In this instance, the cyanide ion serves as the nucleophile.

Also, see:

http://www.cem.msu.edu/~reusch/VirtTxtJml/proteins.htm

http://www.organic-chemistry.org/namedreactions/strecker-syn...

:D




Chemistry is our Covalent Bond
View user's profile View All Posts By User
kazaa81
Hazard to Others
***




Posts: 368
Registered: 30-4-2004
Member Is Offline

Mood: ok

[*] posted on 6-5-2006 at 16:51


Thank you nitroglycol and leu (leucine?)

The synthesis you posted is interesting, I've never hear about it...but one thing dislikes me...HCN, hydrogen cyanide...too much poisoning for me..also for much of we here.

I've heard about this...
Glycine - from chloroacetic acid and ammonia (amino acetic acid)

my goal is to synthetize amino acids of purity not really great (90% or even less), but with impurities not poisoning as cyanides....my impurities would be somewhat like CaCO3...very safe!
View user's profile View All Posts By User
guy
National Hazard
****




Posts: 982
Registered: 14-4-2004
Location: California, USA
Member Is Offline

Mood: Catalytic!

[*] posted on 6-5-2006 at 18:51


Quote:

Glycine - from chloroacetic acid and ammonia (amino acetic acid)


You probably will get a mixture of glycine, ammonium chloride, and 2-chloroethan-1-amide.

[Edited on 5/7/2006 by guy]




View user's profile View All Posts By User
kazaa81
Hazard to Others
***




Posts: 368
Registered: 30-4-2004
Member Is Offline

Mood: ok

[*] posted on 11-5-2006 at 05:22


This thread seems interesting to me...
http://www.sciencemadness.org/talk/viewthread.php?tid=2210#p...

If one escape the last steps, one has a solution of amino acids, from hairs.
However, how make the HCl safe? Like using the solution as food-integrator?
Neutralizing with sodium bicarbonate (NaHCO3)?

any help appreciated
View user's profile View All Posts By User
Niels Bohr
Harmless
*




Posts: 12
Registered: 1-12-2005
Member Is Offline

Mood: No Mood

[*] posted on 11-5-2006 at 05:29


What are you going to use it for. I'm just curious.
View user's profile Visit user's homepage View All Posts By User
kazaa81
Hazard to Others
***




Posts: 368
Registered: 30-4-2004
Member Is Offline

Mood: ok

[*] posted on 11-5-2006 at 05:42


to bohr:

Quote:
Originally posted by kazaa81
......using the solution as food-integrator?.....


Using a solution as food integretor what would mean?

If that's still not clear enough, I would mean using a solution (or powder) of amino acids of the above experiment as an aid in diets poor of some of them. All this from cheap hairs!
View user's profile View All Posts By User
kazaa81
Hazard to Others
***




Posts: 368
Registered: 30-4-2004
Member Is Offline

Mood: ok

[*] posted on 14-5-2006 at 07:28


Any help welcomed

[Edited on 14-5-2006 by kazaa81]
View user's profile View All Posts By User

  Go To Top