itsmetheuglykid
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NaOH as substitute for KOH in methylation of amino alcohols
Reference: http://pubs.acs.org/doi/pdf/10.1021/jo01067a619
Does anyone know why NaOH would not be ideal to use in stratification step in substitute of KOH? Specifically the methylation 1-amino-2-propanol. I
know that NaOH is more hygroscopic than it's buddy, probably helping keep moisture levels lower in the final product. I would prefer not to have to
wait a week for KOH to come in the mail. (no soap making shops where i live)
[Edited on 20-2-2015 by itsmetheuglykid]
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Crowfjord
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In your reference, they use NaOH in one example, and KOH in another. They are just used as base in the workups. Moisture absorbance or solubility
might have played a role in their choice, but I doubt there would be much difference exchanging one for the other in this particular instance.
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chemrox
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I always used KOH for adding solid (flakes) of base. It seems to be easier to visualize the response using KOH rather than with NaOH but I was
following procedures and wondered about it from time to time. For those who would like to read the whole article:
Attachment: ACS-N-Me_ation of amino alcohols and mercaptans.pdf (237kB)
This file has been downloaded 330 times
"When you let the dumbasses vote you end up with populism followed by autocracy and getting back is a bitch." Plato (sort of)
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itsmetheuglykid
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Ya it worked out just fine...thanks.
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