Mason_Grand_ANNdrews
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Acetophenone to Phenylethylamin
I`ve found some good informations to phenylethylamin, D,L-alpha form. Phenylethylamin is obatined by ammonium formiate and acetophenone but the
synthesis way was not verbose described. I guess this is somewhat interested to urea. I don`t know it will work urea and ammonium formiate will give a
guanidinium salt by this way.It can be possible when acetophenone will dissolved with ammonium formiate in anhydrous ethanol and phenylethylamin is
obtained by adding some dilute H2SO4 or HCl to the solution. Any hints to that will help.
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turd
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It's the well-known Leuckart or Leuckart-Wallach reaction. Basically formic acid serves as a hydride donor. It can give decent yields on substrates
which survive the reaction conditions.
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Mason_Grand_ANNdrews
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I`ve read about this. I think the practical issue is important.
I hope i found more to this. If you want to know, the synthesis of ammonium formiate is quite easy. A mix of ammonium carbonate and 85% dilute formic
acid by weight give ammonium formiate. I guess that will work with concentrated formic acid.
[Edited on 7-8-2006 by Mason_Grand_ANNdrews]
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