Sciencemadness Discussion Board
Not logged in [Login ]
Go To Bottom

Printable Version  
Author: Subject: synthesis of acetophenone
lalalympo
Harmless
*




Posts: 12
Registered: 5-9-2016
Member Is Offline

Mood: No Mood

[*] posted on 5-9-2016 at 09:54
synthesis of acetophenone


Hello,

this is my first topic on this forum, I'm a bit of a newbie when it comes chemistry but I'm eager to learn.

So I want to synthesize some acetophenone, the stuff pretty much impossible to get where I live.

I've read about Fiedel-Crafts acylation on some forums but not enough to start to preform this reaction.

I want to dry-distill calcium acetate and calcium benzoate, since it seems the easiest. Could I just dump the two in a RBF? Or does it need a catalyst? If anyone knows how to preform this reaction or has done it I'd be happy to hear about it.

If you have a potentially easier way of making acetophenone (I want to stay away from benzene) you can also tell me
View user's profile View All Posts By User
Nicodem
Super Moderator
Thread Moved
5-9-2016 at 09:59
RocksInHead
Harmless
*




Posts: 39
Registered: 16-6-2016
Member Is Offline

Mood: Highly Nitrated

[*] posted on 5-9-2016 at 10:01


From what I've heard an easy way to make it is by reacting acetyl chloride and benzene over an aluminium chloride catalyst.

http://www.prepchem.com/synthesis-of-acetophenone/
View user's profile View All Posts By User
Metacelsus
International Hazard
*****




Posts: 2532
Registered: 26-12-2012
Location: Boston, MA
Member Is Offline

Mood: Double, double, toil and trouble

[*] posted on 5-9-2016 at 11:46


That's easy only if you have acetyl chloride and benzene. Also note that the OP wants to avoid using benzene.
The same PrepChem page details a synthesis from calcium benzoate and acetate, which is what the OP requested.





As below, so above.

My blog: https://denovo.substack.com
View user's profile View All Posts By User
Dank
Harmless
*




Posts: 8
Registered: 10-4-2016
Location: USA
Member Is Offline

Mood: Wet

[*] posted on 5-9-2016 at 19:54


Wacker oxidation of styrene is an option as well. Chemplayer made a video on the calcium acetate/calcium benzoate method but yields were abysmal IIRC.
View user's profile View All Posts By User
CuReUS
National Hazard
****




Posts: 928
Registered: 9-9-2014
Member Is Offline

Mood: No Mood

[*] posted on 6-9-2016 at 00:16


another method from styrene - http://www.sciencemadness.org/talk/viewthread.php?tid=66322
you could also do a grignard reaction between benzonitrile (made from benzoic acid using urea + sulphamic acid) and MeMgBr
View user's profile View All Posts By User
RocksInHead
Harmless
*




Posts: 39
Registered: 16-6-2016
Member Is Offline

Mood: Highly Nitrated

[*] posted on 6-9-2016 at 03:22


Quote: Originally posted by Metacelsus  
That's easy only if you have acetyl chloride and benzene. Also note that the OP wants to avoid using benzene.
The same PrepChem page details a synthesis from calcium benzoate and acetate, which is what the OP requested.



Oh, sorry. If I would have read down a little lower then I would have seen it, but I was in a rush anyway. Oh well.
View user's profile View All Posts By User

  Go To Top