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Author: Subject: Synthesis of 1-(2-Chloropropyl)piperidine
liftedresearch
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[*] posted on 3-12-2017 at 22:15
Synthesis of 1-(2-Chloropropyl)piperidine


Hello,

Quite frankly I'm stumped as to how one would synthesize this compound, could you n-alkylate the piperidine with 1 chloro 2 propanol? Any help would be much obliged
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PirateDocBrown
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[*] posted on 4-12-2017 at 00:09


You've asked many times for help on synthesis. Could you start posting results?
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[*] posted on 4-12-2017 at 03:05


Quote: Originally posted by liftedresearch  
could you n-alkylate the piperidine with 1 chloro 2 propanol?

I think you could , because I found a ref for the synthesis of 1-(2-chloroethyl)piperidine where they reacted piperidine with 2-chloroethanol and then converted the OH to Cl using thionyl chloride (Maybe TCT/DMF or just HCl could be used ? ) -https://link.springer.com/article/10.1134/S1070427209090134
but a higher yielding method would be to use propylene oxide instead-https://link.springer.com/article/10.1134/S1070363210090173
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