Sciencemadness Discussion Board - The neurochemicals in nature

The neurochemicals in nature

symboom - 4-4-2018 at 22:43

I have been working on a project took a while in categorizing herbs in what general receptors are activated

Serotonin
Dopamine
Adrenaline
NMDA
Opioid
Histamine

Nmda antagonist

Psychotria colorata
psychotridine
hodgkinsine

Psychotria lyciiflora
hodgkinsine
quadrigemine C
isopsychotridine B
psychotridine
quadrigemine
oleoidine
caledonine

Calycodendron milnei
Hodgkinsine

Tabernaemontana divaricata
conolidine
tabernaemontanine,
coronarine,
coronaridine,
dregamine.

Acourous calamus
alpha-asarone,
beta-asarone
gamma-asarone

Hodgkinsonia frutescens
Hodgkinsine

Cats claw
Rhyncophylline
speciophylline
uncarine F
pteropodine
isopteropodine
mitraphylline
isomitraphylline
Isorhynchophylline

Sophora flavescens
Matrine
matrine oxide,
Kushenin
Sophoraflavanone
7,9,2',4'-Tetrahydroxy-8-isopentenyl-5-methoxychalcone
Sophoridine
Trifolirhizin,
8-Prenylkaempferol
Oxysophocarpine
sophocarpine

Corydalis yanhusuo
Dehydrocorybulbine
Glaucine

Glaucium flavum
Glaucine

Croton lechleri
Glaucine

Stephania rotunda
Tetrahydropalmatine

pukatea
Pukateine

Phellodendron amurense
Hodgkinsine

Galbulimima belgraveana
himbacine
Himgrina
Himgravina
Himandravina
Himbelina

Zizyphus jujuba
Sanjoinine A

Cyperus articulatus
alpha-corymbolol,
alpha-cyperone,
alpha-pinene
carophyllene oxide
corymbolone
Cyperotundone,
mustakone.
Cyperotundone
alpha-cyperone.
Articulone,
copaene,
α-corymbolol,
β-corymbolone,
mandassidione
caryophyllene oxide,
trans-pinocarveol,
myrtenal,
myrtenol,
ledol,
Cyperotundone,
alpha-cyperone

Bacopa monnieri
brahmine,
nicotine,
herpestine
D-mannitol,
apigenin,
hersaponin,
monnierasi
bacopaside I
bacoside A3
bacopaside II
bacopasaponin C

Searsia pyroides ethanol extract also depressed the NMDA stimulated increase in intracellular Ca.

Dangers
K hole

NMDA agonist
Dangers
Glutamate toxity

Alanine

Aspartic acid

Glutamic acid

Glycine

Serine

Seritonin agonist
Antidepression
The tryptamine psychedelics, such as DMT and psilocybin, structurally resemble serotonin itself. The phenethylamine psychedelics on the other hand, such as mescaline, and compounds of the 2C family, more closely resemble the neurotransmitter dopamine.

Sceletium tortuosum
mesembrine,
mesembrenone
mesembrenol
Tortuosamine.

Lespedeza bicolor

Yopo
2,9-dimethyltryptoline
2-methyltryptoline
5-MeO-DMT
5-Methoxy-N-methyltryptamine
Bufotenin
Bufotenin-oxide
Catechol
Leucoanthocyanin
Leucopelargonidol
DMT
DMT-oxide
Methyltryptamine
Orientin
Saponarentin
Viterine

Fittonia albivenis

Justicia pectoralis

Prestonia amazonica

Acacia acuminata

Albizia inundata

Voacanga africana

Prestonia amazonica

Delosperma cooperi

Serotonin antagonist

Reserpine Depletes serotonin stores in the brain, heart, and many other organs

Feverfew

red panax ginseng

chastetree

Dopamine agonist
antiparkinson agents are normally agonists and treat ADHD

L-phenylalanine,

L-tyrosine

l_dopa

Mucuna pruriens
L_dopa

Vicia faba
L_dopa

Ulvaria obscura
L_dopa

Chaenomeles speciosa
(Flowering Quince)

Chaenomeles sinensis

Oroxylum indicum
Oroxylin A

Scutellaria baicalensis (Skullcap)
Oroxylin

Dopamine antagonist
Antipsychotics

dopamine antagonists, and as such they have found use in treating schizophrenia, bipolar disorder, and stimulant psychosis

Gaba antagonist
thujone

Thujone
mugwort,
oregano,
common sage
Artemisia absinthium

ginkgo biloba
ginkgolic acids
adipostatin A

kudzu
puerarin
daidzein,
daidzin
genistein
mirificin
salvianolic acid

muira puama
Coumarin,
lupeol
muirapuamine.

Gaba agonist

Amanita muscaria
ibotenic acid
muscimol

Skullcap
wogonin,
wogonoside,
baicalin,
apigenin,
oroxylin A,
scutellarein,
skullcapflavone.

ashwagandha
tropine
cuscohygrine
withaferin A,

chamomile
Apigenin

Albizza juberilone

Kava
ncluding kavain,
dihydrokavain,
methysticin,
dihydromethysticin,
yangonin,
desmethoxyyangonin
flavokavain A,
flavokavain B
Flavokavain C

Adrenergic agonist

Betel nut (areca nut, paan)
Arecoline

Tobacco
Nicotine

butcher's broom
ruscogenin
neoruscogenin

bitter oranage
N-methyltyramine,
octopamine
synephrine

bitter yam

coca (cocaine)
Benzoylecgonine
Cocaine
Ecgonidine
Ecgonine
Hydroxytropacocaine
Methylecgonine cinnamate
Tropacocaine
Truxilline
Cuscohygrine
Dihydrocuscohygrine
Hygrine
Nicotine

ephedra.
ephedrine
pseudoephedrine
norephedrine,
Norpseudoephedrine

Acorus calamus
alpha-asarone
Beta-asarone
gamma-asarone
eugenol

Anamirta cocculus
berberine,
palmatine,
magnoflorine
columbamine

Areca catechu
arecaidine
arecoline,
................
Catuaba
What gives strength to the indian

Trichilia catigua
Cinchonain-Ib

Erythroxylum vaccinifolium.
catuabines.

Other catuaba preparations use the bark of trees from the following genera or families: Anemopaegma, Ilex, Micropholis, Phyllanthus, Secondatia, Tetragastris and species from the Myrtaceae

Holly
caffeic acid,
caffeoyl derivatives,
caffeoylshikimic acid,
Chlorogenic acid,
Feruloylquinic acid,
quercetin,
quinic acid,
kaempferol,
tannins
, rutin,
caffeine
theobromine

...........

chocolate
Theobromide

Contrayerva
contrajervin
cajapine,
dorsjervin A,
dorsjervin B,
psoralen,
dorstenin,
squalene,
γ-sitosterol,
cycloartocarpesin,
1-O-linolenoyl-2-O-stearoyl-3-O-ß-D-galactopyranosyl glycerol,
bergapten,
dorsteniol,
xanthoarnol

Guarana
caffeine
theophylline
Theobromine

Khat
cathinone
cathine

Nicotiana rustica
nicotine nine times more than common tobacco
Harman
norharman

Sida cordifolia
ilima flannel weed, bala, country mallow or heart-leaf sida mallow family
β-phenethylamine
Ephedrine,
pseudo-ephedrine
hypaphorine,
vasicinone,
vasicinol,
choline
betaine.

Tea
4% caffeine
theobromine.

Tobacco
Nicotine
rutin
chlorogenic acid
glutamic acids,
asparagine
, glutamine
γ-Aminobutyric acid
Nornicotine
anatabine
anabasine,
myosmine
cotinine

Yerba mate
Caffeine,
theobromine
theophylline

Yohimbe
yohimbine.
corynanthine

Indian snake root
Rauvolfia serpentina
ajmaline
, ajmalicine,.
ajmalimine,
deserpidine,
indobine,
indobinine,
reserpine,
reserpiline,
rescinnamine,
rescinnamidine,
serpentine,
serpentinine
yohimbine.

Adrenergic antagonist

???

Anticholinergic
spasmolytic, anti-asthmatic, anticholinergic, narcotic and anesthetic

Hyoscyamus niger,

Atropa belladonna,

Mandragora officinarum
hyoscyamine
, hyoscine,
cuscohygrine,
apoatropine,
3-alpha-tigloyloxytropane
, 3-alpha,6-beta-ditigloyloxytropane
belladonnine

Datura

Tassel bush

Nutmeg

Canarium luzonicum

Amanita muscaria

Cholinergic

lemon balm,

sage,

rosemary,

ginkgo,

gotu kola

Chinese club moss

Vinca minor
Vincaminol
vincamine.
reserpine
, reserpinine
, akuammicine
, majdine,
vinerine,
ervine,
vineridine,
tombozine,
vincamajine,
vincanine,
vincanidine,
vincamone,
apovincamine,
vincaminol,
desoxyvincaminol,
vincorine
perivincine.

Nootropics
Alpha-GPC (

Citicoline

Galanthus caucasicus

Tyrosine

Creatine

Histamine agonist?
???

Histamine antagonist
Stinging Nettle
Quercetin.
Bromelain.
Vitamin C.

Opiate agonist

Opium poppy

Kratom

Akuamma
akuammidine,
akuammine,
akuammicine,
akuammigine
pseudoakuammigine.

Periwinkle

Nauclea latifolia
Tramadol

Dalea purpurea
pawhuskin A,
pawhuskin B,
pawhuskin C,
Petalostemumol

Salvia divitorium

Commiphora Myrrh
furanoeudesma-1,3-diene

Peripentadenia Mearsii
- peripentonine A, B, and C,
peripentadenine
mearsamine
Peripentadenine,

Psychotria Colorata
Psychotridine
Hodgkinsine

Nigella Sativa
thymoquinone

Stephania japonica
-8 Hasubanan alkaloids and 1 morphinane alkaloid have been isolated from this vine.

Actaea racemosa-Contains a partial mu-opioid agonist.

Elaeocarpus grandis
grandisine A, B, C, D, E, F, G
isoelaeocarpiline.

Elaeocarpus fuscoides-
elaeocarpenine,
isoelaeocarpicine
, isoelaeocarpine
elaeocarpine .

Opiate antagonist?
???

Cannabinoid agonist
Liverwort
Perrottetinene
Perrottetinic acid

Coneflower – Echinacea
cannabimimetic
N-alkyl amides

Oxeye - Heliopsis helianthoides
cannabimimetic
N-alkyl amides

Electric daisy - Acmella oleracea
N-Isobutylamides

Helichrysum umbraculigerum
cannabigerol

Liverwort – Radula marginata
perrottetinenic acid is remarkably similar to THC.

Chocolate

FAAH is responsible for the breakdown of an endocannabinoid known as anandamide in our bodies. Anandamide is our natural version of THC

Black pepper- Piper nigrum
Beta-caryophyllene (BCP)

Herbs found to engage with the endocannabinoid system. A couple others include Peruvian maca and Chinese rhododendron.

Refrences
https://herb.co/marijuana/news/non-marijuana-plants-contain-...

Efficacy_spectrum.png - 17kB

[

[Edited on 5-4-2018 by symboom]

[Edited on 5-4-2018 by symboom]

nice list

rase - 25-3-2019 at 15:45

Hello,

nice list you have there...

can you tell whats the best sources for that herbs?

Thanks

j_sum1 - 25-3-2019 at 17:20

rase
Your various posts are spamming. I have deleted the worst and sent one thread to detritus.
If you want to contribute or participate then fine.
If you want to add meaningless comments to old threads or ask how to use a tea bag then go somewhere else.

[/modding]

MineMan - 14-5-2019 at 00:01

Symboom. You have k-hole listed under NMDA... is this from herbs? I always thought the k-hole was just from ketamine. If so. These herbs could be potent antidepressants.

karlos³ - 4-6-2019 at 05:30

You have listed Nauclea latifolia as a natural source of tramadol.
That is wrong.
This plant does not biosynthesise that itself, actually the cattle herders feed the cattle massive amounts of tramadol, and when they excrete it and its metabolites out in their urine, it gets absorbed from the plant, that is where it comes from.

SWIM - 4-6-2019 at 10:09

These long lists would be a lot more useful if you included some references and explanatory comments.

You're obviously putting a lot of work into these, but a little more explanation and some citations for each separate material could make them REALLY useful to people who lack your considerable knowledge.

MineMan - 20-7-2019 at 22:17

Agreed. If this list was better organized with explanations it could really help people whom doctors have failed or who want to go the natural path.

symboom - 13-7-2020 at 15:33

Here is what I have been working on it has been hard to find information on what a lot of plants affect in the body. Sometimes the only information I can find is it's a stimulant sedative or for pain relief.
Like categorizing herbs based on what thransmitter they effect serotonin, acetylcholine, gaba, etc...
Next I'll probably compare herbs and their affect on enzyme activation or deactivation.
I'm working on better organizing the information

[Edited on 14-7-2020 by symboom]

[Edited on 14-7-2020 by symboom]

mackolol - 14-7-2020 at 02:58

You can add magnolol and honokiol to your list, which are GABA A agonists naturally occurring in magnolia bark. They are said to work pretty well and even to help in benzodiazepines withdrawal.

BrainAmoeba - 16-7-2020 at 12:49

Nice list. I hope that it will be even more informative after some modifications.

symboom - 16-7-2020 at 14:45

Can't edit it but here is a big list of notropics that don't just increase acetylcholine
https://nootropicsexpert.com/nootropics-list/#rhodiola-rosea

[Edited on 16-7-2020 by symboom]

symboom - 21-7-2020 at 00:11

#DOPAMINERGIC#
Sacred lotus/ Nuciferine - can potentiate morphine analgesia.
Blue lotus/Apomorphine - agonist
Mucuna Pruriens / L-Dopa
Flowering quence - Dopamine reuptake inhibitor
Blue trumpet vine
P corylifolia
Oroxylum indicum/ Oroxylin A - Dopamine reuptake inhibitor
Skullcap/ Oroxylin A - - Dopamine reuptake inhibitor
___________________
# SEROTONERIC#
Kanna / mesembrine, mesembrenone - SSRI
St. John's wort - monoamine reuptake inhibitor (MRI),
Argyreia Nervosa / Ergine(LSA)
Morning glories / Ergine(LSA)
San Pedro / Mescaline
Peyote / Mescaline
Vilca / Bufotenin
Virola Elongata / DMT, 5-MeO-DMT
Red Ucuuba / DMT, 5-MeO-DMT
Jurema / DMT
Acacia species / DMT
Psychtria Viridis / DMT
Psilocybin mushroom / Psilocybin
Dictyonema huaorani / 5-MeO-DMT, DMT, Psilocybin
___________________
#OPIOIDERGIC#
Becche
iboga
Voacanga Africans
Phychotria Colorata
Salvia divatorum
Jupiter sage
Salvia recognia
Opium poppy
Akuamma
Kratom
Mitragyna hirsuta
Mitragyna javanica
_______________________
#ADRENERGIC#
Yerba mate /caffeine, theobromine, and theophylline
Yohimbe / Yohimbine
Coffee / Caffine
Khat - cathinone - SNRI
Tea / Caffine
Sida Cordifolia / ephedrine, pseudoephedrine
Catuba / catuabine A, B, C
Coca / cocaine
Ephedra sinica / ephedrine, pseudoephedrine
Eria Jarensis / N,N-DMPEA
_________________
#CHOLINERGIC#
Snowdrop /Galantamine - acetylcholinesterase inhibitor
Huperzia serrata / Huperzine A - acetylcholinesterase inhibitor
Bacopa Monnier / bacopasides I–XII, brahmine, and herpestine
Polygala Tenifolia
Vinca Minor / vincamine
Intellect Tree
Scotch Broom / Cytisine
Tobacco / Nicotine
Mescalbean /Cytisine
Lobelia Inflata / Lobeline
Areca Catechu / Arecoline
_________________
#CANNABINERGIC
Cannabis
Liverwort
Coneflower – Echinacea
Oxeye - Heliopsis helianthoides
Electric daisy
Helichrysum umbraculigerum
_________________
#GABAergic#
Kava
Valarian root
Magnolia
__________________
#MAOI#
Nutmeg
Ayahuasca vine
Passion flower
Syrian Rue
Grape fruit
Licorice
Black pepper
Tumeric
____________________
#Other Analgesic#
Rhodiola rosea -Endorphin releasing agent and MAOI
Sakae Naa
Incarvillea sinesis
Snapdragon root
Sophora genus
Corydalis
Scullcap
Pukatea
Chuchuhuasi
Lettuce opium
Devil's backbone
White Willow
Cats Claw
yellow horned poppy
_________________
#Other Sedative
Indian snakeroot - antiphycotic
Albiza
Indian warrior
common devil pepper
Silene capensis
_________________
#Other Stimulant
Contrayerba
Goldenseal
Bitter orange
_________________
#Unknown
Rhodiola Crenulata
Wild dagga
Coleus
Galangal
Horse Chestnut
Zornia latifolia
Calamus
Mulungu
Sun Opener
Calea Dream Herb
African dream root
African dream herb
Sugandi dream root

Edit still in progress
May have a short discription. Figured out the best layout for the post to be easier to read.

Intellect tree
celastrine, celapanine, celapanigine, celapagin, malkangunin and paniculatine.

[Edited on 22-7-2020 by symboom]

symboom - 22-7-2020 at 04:47

Neurotransmitters

Amino Acids: glutamate, aspartate, glysine, GABA.
Monoamines: dopamine, serotonin, histamine, noradrenaline.
Peptides: substance p, opioid peptides.
Others: acetylcholine, adenosine, nitric oxide.

Herbs containing an antagonist

Dopamine antagonist
Indian snakeroot
Bacopa
Noni
Magnolia
Licorice

Serotonin antagonist
Rauvolfia serpentina/ Reserpine
Feverfew
Chastetree (vitex Dopamine agonist)

Opioid antagonist
N/A

Norepinephrine antagonist
N/A

Cannabidiol antagonist
N/A

Acetylcholine antagonist
Latua
Mandragora
Hyoscyamus
Duboisia (corkwood tree)
Datura
Brugmansia
Atropa belladonna (Nightshade)
Myristica fragrans (Nutmeg)

GABA antagonist
mugwort,
oregano,
common sage
Artemisia absinthium
Ginkgo biloba
Kudzu
Muira puama

++++++++++++++++++++++++
Dopamine agonists
Used in Parkinson’s disease and, to a lesser extent, to treat depression, hyperprolactinemia and restless legs syndrome.
Parkinson's disease dopaminergic neurons that produce the neurotransmitter dopamine in the brain slowly break down and can eventually die. With decreasing levels of dopamine the brain can't function properly and causes abnormal brain activity, which ultimately leads to the symptoms of Parkinson's disease.
Hyperprolactinemia
Dopamine is a prolactin-inhibiting factor (PIFs) since it lowers the prolactin-releasing factors synthesis and secretion through DD2-like receptors.
Restless leg syndrome is identified by the strong urge to move and is a dopamine-dependent disorder

Dopamine reuptake inhibitors
used in the treatment of attention-deficit hyperactivity disorder (ADHD) and narcolepsy for their psychostimulant effects, and in the treatment of obesity and binge eating disorder for their appetite suppressant effects.

Dopamine releasing agent
These drugs are frequently used for recreational purposes and encountered as drugs of abuse

Dopamine antagonist
treating schizophrenia, bipolar disorder, and stimulant psychosis. Antiemetics used in the treatment of nausea and vomiting.
++++++++++++++++++++++++
Serotonin agonists
They are used variously as antidepressants, anxiolytics, antiobsessionals, appetite suppressants, and entactogens
migraine and cluster headache attacks. The antimigraine effect caused by vasoconstriction of blood vessels in the brain. The same is true for ergotamine. Female sexual dysfunction. Medication for controlling anger (antiaggression effect) Many atypical antipsychotics to effects on negative symptoms in schizophrenia. treating certain disorders of gastrointestinal motility. Other 5-HT4 receptor agonists have shown potential to be nootropic and antidepressant drugs
Valerenic acid, a constituent of valerian root, has been found to act as a 5-HT5A receptor agonist, and this action could be involved in the sleep-promoting effects of valerian

Serotonin reuptake Inhibitor
Antidepressants treatment of anxiety disorders and eating disorders. Less often, SRIs are also used to treat a variety of other medical conditions including neuropathic pain and fibromyalgia

Serotonin releasing agent
appetite suppressants, antidepressants and anxiolytics with the potential for a faster onset of action and superior efficacy relative to the selective serotonin reuptake inhibitors

Serotonin antagonist
Used as atypical antipsychotics, Antihypertensive, treating chemotherapy-induced emesis and postoperative nausea and vomiting, and treatment of irritable bowel syndrome

++++++++++++++++++++++++
Opioid/Opioid peptide
Opioid peptides retain some of the features of opioids, but have distinct clinical characteristics that differentiate them from traditional opioids. Thus they defy simple classification as opioids.
Opioid peptides bind to opioid receptors in the brain; opiates and opioids mimic the effect of these peptides. The effects of these peptides vary, but they all resemble those of opiates. opioid peptides are known to play an important role in motivation, emotion, attachment behaviour, the response to stress and pain, and the control of food intake.

Opioid peptides
endorphin, enkephalins, and dynorphins, and 3 families of receptors, μ (MOR), δ (λ, DOR), and κ (KOR).
https://www.amboss.com/us/knowledge/Opioids
-----------------
Opioid (peptides) releasing agent
Rhodiola rosea
-----------------
Opioid(peptide) reuptake inhibitor
Enkephalinase inhibitors
D-phenylalanine inhibits enkephalinase
effects are Analgesic, antidepressant, anxiolytic, and
antidiarrheal
Endorphinase inhibitors
N/A
Dynorphinase inhibitors
N/A
-----------------
Opioid agonist
Pain relief and antidiarrheal
---------------
Opioid antagonist
These drugs are used mainly in the treatment of opioid-induced constipation. Treatment in opioid dependence to keep away withdrawn symptoms. antidote drug for treating opioid overdose.

++++++++++++++++++++++++
Norepinephrine
Norepinephrine agonist
Norepinephrine increases alertness and arousal, speeds reaction time and ability to concentrate. Norepinephrine used as a stimulant, an antidepressant and for treatment of ADHD
A2 norephedrine Agonist induces sedation, anesthesia, muscle relaxation, and analgesia

Norepinephrine reuptake inhibitor
NRIs are commonly used in the treatment of conditions like ADHD and narcolepsy due to their psychostimulant effects and in obesity due to their appetite suppressant effects. They are also frequently used as antidepressants for the treatment of major depressive disorder, anxiety and panic disorder. Add

Norepinephrine releasing agent
For the treatment of attention deficit hyperactivity disorder (ADHD). As an appitite suppressant in the treatment of obesity. As wakefulness-promoting agents in the treatment of narcolepsy and as nasal decongestants

Norepinephrine antagonist
Used for vasodilation of blood vessels, lowering blood pressure and relieving hypertension. It's used to relieve the pain caused by myocardial infarction, and also the infarction size, which correlates with heart rate. Also used for treatment of ureteric stones, pain and panic disorders, withdrawal, and anesthesia

++++++++++++++++++++++++
Acetylcholine
Acetylcholine releasing agent
Treatment of Eaton-Lambert syndrome occurs when the immune system attacks nerve cells causing muscle weakness

Acetylcholine agonist
as Alzheimer's disease, schizophrenia, attention-deficit hyperactivity disorder (ADHD) Glacoma and nicotine addiction and muscle relaxant

Acetylcholine reuptake inhibitor
Used to treat myasthenia gravis as it increases neuromuscular transmission. To treat glaucoma, To treat postural tachycardia syndrome, As an antidote to anticholinergic poisoning, To reverse the effect of non-depolarising muscle relaxants
To treat neuropsychiatric symptoms of diseases such as Alzheimer's disease, particularly apathy
To increase chances of lucid dreaming (by prolonging REM sleep)
To treat Alzheimer's disease, the Lewy body dementias and Parkinson's disease to treat the cognitive (memory and learning deficits mostly) symptoms of dementia. To attenuate psychotic symptoms (especially visual hallucinations) in Parkinson's disease. To treat cognitive impairments in patients with schizophrenia in treating positive, negative and affective symptoms. As a treatment for autism to increase Rapid eye movement sleep in autistic children, in line with the mechanism by which they encourage lucid dreaming.

Acetylcholine antagonist
muscarinic acetylcholine antagonist, a type of anticholinergic, which works by causing smooth muscles to relax used in the eye for dilating the pupil for an eye examination
Nicotinic acetylcholine antagonist
prevent motion sickness and used in the treatment of COPD by relaxing the smooth muscles
++++++++++++++++++++++++
Cannabidiol agonist
For treating vomiting and for enhancement of appetite, mainly in people with AIDS as well as for refractory nausea and vomiting in people undergoing chemotherapy. To alleviate neuropathic pain, spasticity, overactive bladder.

(Cannabidiol)anandamide reuptake inhibitor: black pepper
suppression of pain perception (analgesia), increased appetite, mood elevation and inhibition of short-term memory.

(Cannabidiol) anandamide releasing agent
Chocolate (theobromine, phenethylamine)
elevated anandamide levels causes an immunity to anxiety, unable to experience fear and insensitive to pain. healing quicker than average.

Cannabidiol antagonist
to treat obesity and as a smoking cessation agent
++++++++++++++++++++++++
GABA
Gaba agonist
A anxiolytic, anticonvulsant, and muscle relaxant.

GABA reuptake inhibitor
A anxiolytic, anticonvulsant, and muscle relaxant.

Gaba releasing agent
N/A

GABA antagonist
produces stimulant effects, and are mainly used for counteracting overdoses of sedative drugs. And as reversing sedation.
++++++++++++++++++++++++
## Glutamate agonist ##
The AMPA receptor
mimics the effects of the neurotransmitter glutamate
Uses as a neutropic: effects are. Acuity enhancement, Colour enhancement, Auditory enhancement, Mindfulness, Tactile enhancement, Wakefulness, Anxiety suppression ,Thought connectivity, Focus enhancement, Immersion enhancement
Motivation enhancement, Memory enhancement, and Dream potentiation

The NMDA receptor
hypofunction of NMDA receptors (due to glutathione deficientcy are involved in impairment of synaptic plasticity
The kainate receptor (KAR)
kainate receptors in the presynaptic cell can affect the amount of neurotransmitters that are released. This effect may occur quickly and last for a long time, and the effects of repetitive stimulation of KARs can be additive over time

Glutamate reuptake inhibitor
Theanine is an analog of this amino acid, and its primary amide, L-glutamine

Glutamate antagonist
AMPA receptor antagonists
anticonvulsants used in patients with epilepsy in the treatment of partial-onset seizures
AMPA antagonist are liable to be abused; very high doses produced euphoria responses similar to ketamine. Side effects of the AMPA antagonist are dizziness, somnolence, vertigo, aggression, anger, loss of coordination, blurred vision, irritability, and slurred speech.
NMDA receptor antagonist
They are commonly used as anesthetics for animals and humans; the state of anesthesia they induce is referred to as dissociative anesthesia.NMDA receptor overactivation is implicated in excitotoxicity, NMDA receptor antagonists have held much promise for the treatment of conditions that involve excitotoxicity, including benzodiazepine withdrawal, traumatic brain injury, stroke, and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's

How glutamate antagonists work. Low doses of glutamate antagonists have been shown to slow down the rate of nerve cell loss in the brain, thereby slowing down the progression of Parkinson's. Glutamate antagonists work by inhibiting the activity of glutamate receptors in the brain.

MAOI
Uses
MAOIs have been found to be effective in the treatment of panic disorder with agoraphobia, social phobia, atypical depression or mixed anxiety disorder and depression, bulimia, and post-traumatic stress disorder,as well as borderline personality disorder and Obsessive Compulsive Disorder (OCD). Bipolar depression , dysmorphophobia, and avoidant personality disorder, Parkinson's disease by targeting MAO-B in particular. MAOI is used to treat migraine prophylaxis dysthymia and hysteroid dysphoria

+++++++++++++++++++++++++++++++++
Adenosine
adenosine agonists suppress seizures and raise seizure thresholds, induces sleep.

Adenosine reuptake inhibitor
used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes. stimulates glucose uptake, suppressing (cell death) apoptosis by reducing production of reactive oxygen compounds inside the cell.
Interesting study on adenosine
improved performance in endurance-type exercise, by converting fast-twitch muscle fibers to the more energy-efficient, fat-burning, slow-twitch type. Given to mice that did not exercise, this combination activated 40% of the genes that were turned on when mice were given GW1516 and made to exercise. This result drew attention to the compound as a possible athletic endurance aid.

adenosine antagonist .Examples include caffeine, theophylline, and theobromine. Stimulant and Inflammation reducer

References
wikipedia.com
ScienceDirect.com
Tandfonline.com
https://www.ncbi.nlm.nih.gov/pmc/

[Edited on 23-7-2020 by symboom]

[Edited on 23-7-2020 by symboom]

symboom - 12-8-2020 at 06:15

Well my project has helped me greatly I'm still working on reducing the need for some of them such as the reuptake inhibitors. And leaving the building block chemicals to stay.

Agonists could be used but it's better to work with the body

Dopamine - motivation/concentration(tyrosine/andrafil)
Acetylcholine - memory/Nitric oxide increase(a-gpc/huperzine)
Beberine - blood sugar control
Rhodiola rosea pain relief /stamina- endorphan releasing agent
Vitamin b complex

Nootropics
I've tried nooept but that is another level of focus visually and Auditory enhancing the senses and cause sensory overload

Relaxation kava or 5-htp
Wakefulness Mugwort gaba antagonist

This has helped me with having a sharper mind and then I decided I might as well exercise more too due to increased energy levels trust me it sucks feeling tired most of the time

There is still more refinements to be made to the list of neurochemicals

[Edited on 12-8-2020 by symboom]

symboom - 18-8-2020 at 05:06

Analgesic receptors(pain relief)
Opioid - kratom/sakae naa
Opioid peptide - rhodiola rosea
Adenosine agonist- incarvillea sinesis
Opioid lettuce - adenosine receptor agonist/anticholinergic
Cannabinoid - cannabis/Zornia latifolia
Gaba agonist - skullcap

yellow horned poppy (simular to gabapentin)
PDE4 inhibitor and calcium channel blocker,
Related to energy
Kanna PDE4 inhibitor and acetylcholinesterase inhibitor

Vitex D2 Dopamine agonist
Opioid peptide releasing agent

TAAR1 agonist PEA, p-tyramine

Sigma agonist
Sigma1
Methylphenylpiracetam
Berberine

[Edited on 19-8-2020 by symboom]

symboom - 20-9-2020 at 07:55

Here is my herbal organization grouped in columns of

serotonin, adenosine, MAOI, opioid, cannabioid, gaba antagonist

acetylcholine dopamine adrenaline
glutamate(nmda anta/AMPA) and gaba

I have been going one by one and seeing how each reacts with me a different one each day. I've also been trying to figure out organizing the columns by increasing receptor activation as you can see with the building block chemicals to the reuptake inhibitors then to the agonists.

[Edited on 20-9-2020 by symboom]

symboom - 27-9-2020 at 01:15

Glutamate agonist
Willardiine occurs naturally in Mariosousa willardiana and Acacia sensu lato (mimosa, acacia, thorntree or wattle)
_______________

Opioid antagonist
Pawhuskin A, B, C
Dalea purpurea (Purple prairie clover)
The pawhuskins possess affinity for the opioid receptors and pawhuskin A, the most potent of the three, acts as an antagonist of mu, kappa, and sigma opioid receptors.

Forskolin is an indirect KOR antagonist
------------------
Opioid
In addition to interrupting pain, they inhibit enzymes known as adenylyl cyclases (ACs) that convert cells’ energy currency, ATP, into a molecule involved in intracellular chemical communication known as cyclic AMP (cAMP). Chronic opioid use can make cells increase the activity of ACs to compensate, causing cAMP levels to skyrocket. When opioid users try to stop using, their cAMP levels remain high, and drugs that reduce those levels—like buprenorphine—have unwanted side effects.
Excerpt.
https://www.sciencemag.org/news/2017/02/new-class-painkiller...
_____________
Topical pain relief
Arnica
Cloves
Electric dasiy (toothache plant)

--------------------
I thought this was interesting the antidote for deadly night shade is another poisonous plant that is extremely cholinergic effects.
Atropa belladonna has unpredictable effects.The antidote for belladonna poisoning is physostigmine the same as for atropine

physostigmine
A reversible cholinesterase inhibitor. It occurs naturally in the Calabar bean and the Manchineel tree

[Edited on 27-9-2020 by symboom]

symboom - 27-9-2020 at 19:29

Natural chemicals that affect enzymes
Main drug metabolism
https://en.m.wikipedia.org/wiki/Drug_metabolism
These chemicals affect the elimination of drugs from the body

Drug metabolism is divided into three phases. In phase I, enzymes such as cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics. These modified compounds are then conjugated to polar compounds in phase II reactions. These reactions are catalysed by transferase enzymes such as glutathione S-transferases. Finally, in phase III, the conjugated xenobiotics may be further processed, before being recognised by efflux transporters and pumped out of cells. Drug metabolism often converts lipophilic compounds into hydrophilic products that are more readily excreted.

Maoi/cytochrome P450

Enzyme inducer or inhibitor
Enzyme activator or enzyme repressor

Oxidation
Cytochrome P450 monooxygenase system
Flavin-containing monooxygenase system
Alcohol dehydrogenase and aldehyde dehydrogenase
Monoamine oxidase
Co-oxidation by peroxidases
Reduction
NADPH-cytochrome P450 reductase

Hydrolysis
Esterases and amidase
Epoxide hydrolase

https://en.m.wikipedia.org/wiki/List_of_cytochrome_P450_modu...
InH=inhibitor
InD=inducer

CYP1A1 -->InH(cumin/turmeric/peppermint/ chamomile/dandelion/Caffeine/Echinacea/grapefruit /St.John's wort ) InD(Insulin/Modafinil/Phenytoin./Tobacco)
CYP1B1 -->InH(St John's wort) InD(. )
CYP2A6 -->InH( Entacapone/Fenofibrate/grapefruit
/Gabapentin/Modafinil/Nicotine/starfruit) InD(. )
CYP2B6 -->InH(Tumeric, Phenytoin ) InD(. )
CYP2C9 -->InH(Ginkgo biloba /St. John’s Wort/Modafinil)
InD(Phenytoin/ St. Johns Wort)
CYP2C19 -->InH(JWH-018/Modafinil InD(. )
CYP2D6 -->InH(Aspirin /Phenytoin/ Cannabidiol
/Cocaine/ Diphenhydramine /St. Johns Wort) InD(. )
CYP2E1 -->InH(Watercress /Niacin) InD(. )
CYP3A4>InH(grapefruit/Ginkgo biloba/ Milkthistle/ Niacin /Piperine/ Quercetin/Star fruit/Valerian) InD(St John's wort/
/Capsaicin/ Modafinil/ Phenytoin)

Goldenseal, with its two notable alkaloids berberine and hydrastine, alters P450-marker enzymatic activities (involving CYP2C9, CYP2D6, and CYP3A4).

Aromatase
The inhibition of aromatase can cause hypoestrogenism (low estrogen levels). The following natural products have been found to have inhibiting effects on aromatase.

Apigenin
Arimistane
ATD
Catechin
Chalcones
Eriodictyol
Hesperetin
Isoliquiritigenin
Mangostin
Myosmine
Nicotine
Resveratrol
Reversitol
Vitamin E
Zinc
Synthetic
Clomiphene
Arom-x
Extracts of certain (white button variety: Agaricus bisporus) mushrooms have been shown to inhibit aromatase in vitro

Enzymes involved with neurochemicals
Norepinephrine/dopamine

Phenylalanine hydroxylase(phenylalanine to tyrosine)
InH(. ) InD ( .)

tyrosine hydroxylase (tyrosine to L-DOPA)
InH(. ) InD ( .)

Thyroid hormones and enzymes

[Edited on 28-9-2020 by symboom]

symboom - 8-10-2020 at 01:51

Norepinephrine releasing agent
Hordenine
Phenylpropanolamine

Thermogenics
increases the basal metabolic rate, thereby increasing energy expenditure

2,4-Dinitrophenol (DNP)
Phentermine
Synephrine
Phenylethylamine
ephedrine
Caffeine

Natural
goshuyu (evodia fruit)
Synephrine, Evodiamine
glucomannan

[Edited on 8-10-2020 by symboom]

symboom - 20-10-2020 at 15:16

www.wired.com/story/resiniferatoxin

Resiniferatoxin is 10,000 times hotter than the hottest pepper, and has features that make it promising as a painkiller of last resort.

This is interesting something that is toxic yet can cure chronic pain

Herbs that can simulate runners/rowers high
specifically phenethylamine , β-endorphin and anandamide.
Phenylethylamine, rhodiola rosea, CBD/Liverwort

Besides exercise, a medicinal herb, Rhodiola rosea is known to release beta-endorphins in the brain. This herb is used as an anti-depressant, where Rosiridin is the medicinal component of Rhodiola sachalinensis. Rosiridin can inhibit monoamine oxidases A and B

Pain sensation
Glutamate
Substance P
Calcium

Pain killer glutamate antagonist

neurotransmitters such as glutamate and substance P cannot be released from the presynaptic terminal of the neurons. These neurotransmitters are vital in the transmission of pain, and as β-Endorphin reduces the release of these substances, there is a strong analgesic effect.

deactivation of the calcium channel causes membrane hyperpolarization.

This is important because pain can cause a person to become inactive which in turn can cause wasting disease and muscle autotrophy.

[Edited on 20-10-2020 by symboom]

FragranceLover89 - 27-10-2020 at 09:23

I am truly concerned with your AST/ALT levels symboom if you take any of that stuff. I had a close call taking Funtumia elastica for allergies and focus (3-Histamine antagonist). I only took 50 mg of the bark a day (much much less than recommended dose) and a random doctor appointment showed that my AST/ALT were at 50% mortality levels. Turns of Conessine (alkaloid) is a PPI and I messed up my liver. And I had no symptoms whatsoever. I am now diagnosed Adhd and it has really helped me. I spend less on supplements except TUDCA. lol

[Edited on 27-10-2020 by FragranceLover89]

[Edited on 27-10-2020 by FragranceLover89]

[Edited on 27-10-2020 by FragranceLover89]

[Edited on 27-10-2020 by FragranceLover89]

symboom - 27-10-2020 at 10:47

Histamine antagonist I don't have allergies so I don't need it. I'm sorry that happened. I don't use these herbs all the time but I wanted to catalogue them but receptor because there is no complete list with so little information. I think the pharmacology is interesting. Thank you about this warning about the plant some of them are great benefit but Are also poisons contain in them such as the plant that metformin is made from.

[Edited on 27-10-2020 by symboom]

FragranceLover89 - 29-10-2020 at 16:55

H3 antagonists are used primarily for narcolepsy but also might be useful for ADHD, Schizophrenia, and Alzheimer's disease.
https://en.wikipedia.org/wiki/H3_receptor_antagonist

karlos³ - 24-11-2020 at 01:11

You might be interested in the findings of this paper: 10.3923/ijbc.2015.235.248
The really interesting bit is the following "Interestingly traces of psychoactive elements were detected. 4-methyl-2,5-dimethoxyphenethylamine, phenethylamine, 2-methoxy-alpha-methyl-4,5-(methylenedioxy)-derivative of phenethylamines have been reported to have psychedelic effect on humans.
Those are the psychedelic 2C-D and the empathogen MMDA-2, first time found in nature!

symboom - 1-1-2021 at 03:38

Albizia seems to act simular to kanna

Active compound Quercitrin in

Botanical name: albizia julibrissin. Pharmaceutical name: Flos Albiziae.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889836/

https://planetherbs.com/research-center/specific-herbs-artic...

[Edited on 1-1-2021 by symboom]

Kanna extract analysis

symboom - 4-1-2021 at 23:04

Here is a report I got with my kanna extract

IMG_20210105_010027713_BURST000_COVER_TOP~2.jpg - 1.1MB

Here is an NMR of matrine and general information about the extract

[Edited on 5-1-2021 by symboom]

scienceboi - 5-1-2021 at 09:15

I really enjoy this thread. SM mostly stays away from "pharma type" chemicals and there's good reason for that. However, your effort of cataloging the various neurochemicals that plants and fungi naturally make is appreciated.

My favorite of your list so far is Hodgkinsine. I'd take a guess that it would replace kratom if kratom is fully illegal and scheduled.

symboom - 5-1-2021 at 09:48

Thank you that's great to hear.
akuamma is normally used as the replacement of kratom In places where it is illegal it is very similar herb that is from Africa unlike Kratom which is from Asia. They are very similar in that they are both partial opioids.
I put a lot of effort in this thread I was frustrated that there is so little research being done on these plants due to synthetic equivalent compounds already existing but now researches are discovering that there are better and safer alternatives from nature
So little information is found about many of the herbs I think it has to do with cost if a pharma company need to make a compound it is made syntheticly rather than extracted
Here is the research on kratom compounds and why a future synthetic partial opioid based on the structure kratom is being considered.
(Synthetic because a plant can't be patented)
https://pubs.acs.org/doi/10.1021/jacs.6b00360

MGM-9 kratom synthetic analog
https://www.sciencedirect.com/science/article/abs/pii/S00283...
And other MGM compounds
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067406/

Hodgkinsine is unfortunately hard to find a lot of information about.

[Edited on 5-1-2021 by symboom]

[Edited on 6-1-2021 by symboom]

karlos³ - 5-1-2021 at 12:39

I have almost two kilos of akuamma(I even got a fresh fruit directly from a German farmer in Ghana but sadly the seeds haven't germinated without going through an elephants digestive system) but I have to say, its not a replacement for kratom.
It is pretty good against pain and cold and the flu, and thats really where its strength is, but it is not an euphoric opioid in the same manner as kratom.

symboom - 10-3-2021 at 18:44

Serotonin //SRI
Dopamine //DRI
Noradrenaline // NRI
Cannabioid // CBRI
Opioid // ORI
Acetylcholine //CRI
Adenosine // AdRI
Glutamate
-NMDA/glycine // GRI
-AMPA
GABA
Histamine

--+--
#DOPAMINERGIC#
Phenylalanine - BB
Tyrosine - BB
Mucuna Pruriens/ L-Dopa - BB
Phenethylamine - BB
Flowering quence - DRI
Blue trumpet vine - DRI
Oroxylum indicum/ Oroxylin - DRI
Skullcap/ Oroxylin A - DRI
Sacred lotus/ Nuciferine- agonist
Blue lotus/Aporphine - agonist
sacred bamboo - antagonist
Vitex - Antagonist
Stephania intermedia /Tetrahydropalmatine - Antagonist
------
Armodafinil - DRI
Modafinil - DRI
Adrafinil - DRI
Phenylpiracetam (NDRI)
___________________
# SEROTONERIC#
Lithium Carbonate
Tryptophan - BB
5HTP - BB
Sam_e - BB
Saffron - SRI
Kanna / mesembrine - SRI
St. John's wort - monoamine reuptake inhibitor (MRI)
Albiza - agonists
Morning glories / LSA - agonist
Argyreia Nervosa / LSA - agonist
Shroom / Psilocybin - agonist
Achuma / Mescaline - agonist
Yopo / Bufotenin- agonist
Cumala / DMT - agonist
Mimosa Hostilis/ DMT - agonist
Acacia confusa / DMT - agonist
Psychtria Viridis / DMT - agonist
D. huaorani / DMT - agonist
Feverfew - antagonist
Peppermint / Menthol - Antagonist
Indian snakeroot - Antagonist
___________________
#OPIOIDERGIC#
R. Rosea - ORI
Vitex - ORI
Opium poppy - agonist
Kratom - agonist
Akuamma - agonist
Sakae naa - agonist
Mitragyna Hirsuta - agonist
Mitragyna Javanica - agonist
Jamaican dogwood - agonist
iboga - k agonist
Salvia divatorum - k agonist
Psychotria Colorata - k agonist
Becche - k agonist
Voacanga Africans - k agonist
Jupiter sage - k agonist
Salvia recognia - k agonist
Cats claw - k agonst
Calycodendron milnei - k agonist
Purple prairie clover - Antagonist
Forskolin - k Antagonist
_______________________
#ADRENERGIC#
Tyramine - BB
NMT:N-methyltyramine - BB
Hordenine
Phenylethylamine - BB
Synephrine - BB
Octopamine - BB
DMBA
DMAA
DMAE
Bitter orange - BB
Coca / cocaine - SNDRI
Khat - cathinone - SNRI
Catuba / catuabine - NDRI
Yohimbe / Yohimbine - NDRI
S. Cordifolia / ephedrine - agonist
Ephedra / ephedrine - agonist
Eria Jarensis / N,N-DMPEA agonist
Coffee arabica / Caffine - agonist
Theacrine - agonist
Theobromine - agonist
Theanine - agonist
Theophylline - agonist
Methylliberine - agonist
Propylhexedrine - agonist
Levmetamfetamine - agonist
Epinephrine - agonist
Methylphenidate - NDRI
Adderall - NDRI/ NDRA
Potassium - antagonist
arginine - antagonist
rauwolfia serpentina - antagonist
Berberis vulgatis- antagonist
Magnesium - antagonist
_________________
#CHOLINERGIC#
Building Blocks
Phosphatidy serine
NAC
aGPC
Citicoline
Sarcosine
Taurine
Uridine phosphate
* CRI choline reuptake inhibitor*
Snowdrop /Galantamine - CRI
H. serrata / Huperzine A - CRI
Vinca Minor / vincamine - CRI
Polygala Tenifolia - CRI
Corydalis yanhusuo - CRI
Scotch Broom / Cytisine - agonist
Tobacco / Nicotine - agonist
Mescalbean /Cytisine - agonist
Lobelia Inflata / Lobeline - agonist
Areca Catechu / Arecoline - agonist
Tobacco / nicotine - agonist
Intellect Tree
Bacopa Monnieri
Nebracetam - agonist
Colouracetam - CRI
phenylpiracetam - CRI /NDRI
BIIB-104 - AMPA Pam / GRI
Chamomile - Antagonist
Datura - Antagonist
Mandrake - Antagonist
Henbane - Antagonist
Nightshade - Antagonist
Labrador tea - Antagonist
Mad honey - Antagonist
Nutmeg - Antagonist
----
Methylphenylpiracetam - positive allosteric modulator of the sigma-1 receptor.
nefiracetam - gabaA agonist
Dimiracetam - relief of neuropathic pain
Seletracetam - SV2A agonist
Levetiracetam - SV2A agonist

_______________
#GLUTAMATERGIC#

AMPA
Glutamate – endogenous agonist
L-Theanine - glutamate reuptake inhibitor
Amanita muscaria / Ibotenic acid - agonist
Quisqualic acid – agonist
Willardiine – agonist
Cordycepts - AMPA Pam
Maitake - AMPA Pam
Noopept - AMPA Pam/ CRI
Aniracetam- AMPA Pam
Pramiracetam- AMPA Pam
Piracetam- AMPA Pam/ calcium channel blocker
Oxiracetam - AMPA Pam/ CRI
Pepa - AMPA Pam /GRI
Fasoracetam - AMPA Pam
Gabapentin - calcium channel blocker
Levetiracetam - calcium channel blocker

Glycine
Sarcosine - glycine reuptake inhibitor
Taurine - glycine reuptake inhibitor
Serine - glycine agonist
Uridine Monophosphate
BIIB-104 GRI

NMDA
Glutamate - agonist
D-Serine - agonist
Dehydroepiandrosterone/ DHEA - agonist
Xenon - Antagonist
Nitrous oxide - Antagonist
Magnesium glycinate - Antagonist
Dextromethorphan (DXM) - Antagonist
Sophora flavencences - Antagonist
Psychotria colorata - Antagonist

--------
#ADENOSINE#
Cordycepts - agonist
inosine - agonist
Incarvillea sinensis - agonist
Lactuca virosa - agonist
Calcium channel blockers AdRI
Benzodiazepines - AdRI
Progesterone DHEA - AdRI
Tricyclic antidepressants - AdRI
Caffeine - Antagonist
theophylline - Antagonist
theobromine - Antagonist
_________________
#CANNABINERGIC
Cannabis
Liverwort
black pepper - CBRI
Coneflower – Echinacea
Oxeye - Heliopsis helianthoides
Electric daisy
Helichrysum umbraculigerum
Palmitoylethanolamine - CBRI
_________________
#GABAergic#
Rubidium Bromide
GABA - BB
Thyme - GRI
Cloves - GRI
Skullcap - GRI
St John's wort - GRI
Ashwaganda - GRI
GABOB - agonist
Kava - agonist
Damiana - agonist
Valarian root - agonist
Mulungu - agonist
Magnolia - agonist
Albiza - agonist
Indian warrior - agonist
Amanita muscaria - agonist
Areca catechu - agonist
Phenibut - agonist
Wild dagga
Mugwort - antagonist
Kudzu - antagonist
Muira puma - antagonist
__________________
#MAOI#
Nutmeg
Ayahuasca vine
Passion flower
Syrian Rue
Grape fruit
Licorice
Black pepper
Tumeric
R. Rosea
Yohimbine
Tobacco
Kava
Olives
Betel nut
--------------------
P450 inhibitor
St johns wort
Starfruit
Goldenseal
Water Crest
____________________
#Other Analgesic#
Rhodiola rosea -Endorphin releasing agent and MAOI
Sakae Naa
Jewel vine
Incarvillea sinesis
Snapdragon root
Sophora genus
Corydalis
Scullcap
Pukatea
Chuchuhuasi
Lettuce opium
Devil's backbone
White Willow
Cats Claw
yellow horned poppy
_________________
#Other Sedative

Silene capensis
_________________
#Other Stimulant
Contrayerba
Goldenseal
Bitter orange
_________________
#Unknown
Rhodiola Crenulata
Wild dagga
Coleus
Galangal
Horse Chestnut
Zornia latifolia
Calamus
Mulungu
Sun Opener
Calea Dream Herb
African dream root
African dream herb
Sugandi dream root

Heat receptor
Cayenne peppers/Capsaicin

Cold receptor
Peppermint /Menthol

Pain receptor (topical)
Benzocaine
Lidocaine
Arnica
Cloves
Electric dasiy (toothache plant)

_________
__Ginseng__
Peruvian - Maca
Indian - Ashwaganda
Female - Angelica sinensis / dong quai
Malaysian - Tongkat ali
Brazilian - Suma
Alaskan - Devil's club
Siberian- Eleuthero
--------
__Steroid phytoandrogen__
DHEA
HMB
Horny goat weed
Tribulus terrestris
Wild yam
Eucommia ulmoides
Galangal
_______

Blood vessel dilator (NO)
Beets
Niacin
Beta alanine
Arginine
Agmatine
________

Blood sugar
thiamine
B complex
Niacin
Creatine
Berberine
Gymnema Sylvestre
-------
Pain relief
Adenosine
Opioid
Dopamine
Norephedrine
Sertonin
COX-2
Glutamate antagonist (NMDA antagonist)

Smarts
AMPA
Glycine
Acetylcholine
Dopamine/Norephedrine
Serotonin

Energy
Norephedrine/dopamine
Glutamate/Acetylcholine

Relaxant
Cannabidiol
Gaba
Opioid
Adenosine
Dopamine
Serotonin/melatonin

Category:Receptor_agonists
https://en.m.wikipedia.org/wiki/Category:Receptor_agonists

Category:Drugs_by_psychological_effects
https://en.m.wikipedia.org/wiki/Category:Drugs_by_psychologi...

[Edited on 11-3-2021 by symboom]

XeonTheMGPony - 11-3-2021 at 03:25

Quote: Originally posted by symboom

Thank you that's great to hear.
akuamma is normally used as the replacement of kratom In places where it is illegal it is very similar herb that is from Africa unlike Kratom which is from Asia. They are very similar in that they are both partial opioids.
I put a lot of effort in this thread I was frustrated that there is so little research being done on these plants due to synthetic equivalent compounds already existing but now researches are discovering that there are better and safer alternatives from nature
So little information is found about many of the herbs I think it has to do with cost if a pharma company need to make a compound it is made syntheticly rather than extracted
Here is the research on kratom compounds and why a future synthetic partial opioid based on the structure kratom is being considered.
(Synthetic because a plant can't be patented)
https://pubs.acs.org/doi/10.1021/jacs.6b00360

MGM-9 kratom synthetic analog
https://www.sciencedirect.com/science/article/abs/pii/S00283...
And other MGM compounds
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6067406/

Hodgkinsine is unfortunately hard to find a lot of information about.

[Edited on 5-1-2021 by symboom]

[Edited on 6-1-2021 by symboom]

well it has more to do with variation in dosage and potency, it is difficult to get a accurate clinical does with a plant as nature feels no need to abide by our dosing measures, one way to compensate is to make large batch, titrate the dose, then use that batch at established dose.

Then be sure to prepare the next batch and do the same in advance befor the first runs out, with purified extracts that been concentrated this extra labor and testing becomes irrelevant as you know the exact amount of compound per dose.

and by just making the compound you skip the rest of the cultivation step and then extraction steps.

Good knowledge to have indeed as humans seem to be getting dumber as a whole I'd prefer to take care of my own medical needs and any system that says I can't will get helpful suggestions of where I will place my boot!

symboom - 7-5-2021 at 23:09

I think this was interesting and it is related to neuro chemistry

Neurochemical effects on the body

Opioid
Pain relief
Diarrhea relief
Appetite suppressant
Supposingly Cough relief
Can cause nausea
Overdose
Shortness of breath
--------------
Serotonin
Pain relief
Dry mouth
Cause weight loss
Laxative
Excessive Yawning
--improves mood

Overdose
Shortness of breath (serotonin syndrome)

Blocking serotonin
Increases body temperature
induce sleep
Antiemetic
Gains weight
---------------
Dopamine
Wakefulness promoting
Decreased appetite
Treats Parkinson’s disease
Treats hyperprolactinemia
restless legs syndrome relief
Raises sex drive
Can cause neasea
--motivation
--concentration

Blocking dopamine
induce sleep
Antiemetic
--------------

Norephedrine
Dry mouth
Bronchodilation
increases heart rate and force
constricts blood vessels
treating septic shock
Raise of adrenaline blocks histamine production
--motivation

Blocking Norephedrine
induce sleep
------
GABA
antiemetics
Pain relief
induce sleep
Lowers heart rate and force
--slows down thinking
--------
Acetylcholine
Laxative
Increases salivation
Excessive Yawning
Responsible for rest and aids digestion
contracts smooth muscles, dilates blood vessels, increases bodily secretions, and slows heart rate

Anticholinergics
Causes dry mouth
antiemetics
Bronchodilation
anticholinergics can reduce the acetylcholine-induced inflammatory response
--memory
-------

Histamine
Premotes wakefulness
Vasodilation and lowers blood pressure
Affects mucus membrane
Gastric acid release
Body temperature
Endocrine
Pain

Antihistamine
Antiemetic
Used as an antiacid (decreases production of stomach acid)
Promotes sleep
Causes weight gain(lowers thermogenesis)
antihistamine that can affect urination. It does so not by affecting the prostate, but by reducing the bladder's ability to contract.
------
Cannabinoids
Pain relief
antiemetics
Premotes sleep
--------
Other receptors

Adenosine
Treats supraventricular tachycardia
anti-inflammatory or immunosuppressive

tachykinin receptor
NK-1 antagonists boost the efficacy of 5-HT3 antagonists
-----------

bronchodilating drugs are β2("beta two")-adrenergic agonists (short- and long-acting), anticholinergics (short- and long-acting), and theophylline (long-acting).
----------
Relation to other neuroreceptors

--Raising serotonin decreases production of dopamine.

--blocking histamine can also block Acetylcholine production

--Acetylcholine can increase dopamine levels

--Histamine causes an increase in glutamate release
NMDA receptor (Glutamate) antagonists increase the serotonin levels in the brain

-- The dopamine-releasing effect of glutamate is mediated by AMPA (rather than NMDA) receptors.

---- Rasing Norephedrine decreases production of histamine
The body cannot handle large amounts of histamine. As a result, the body will counter-act histamine by producing Epinephrine (adrenaline) which helps to de-activate histamine. Sometimes high levels of adrenaline can result in unwanted anxiety and panic attacks.
------------
Agonst vs antagonist
Antagonist increase a receptors production making more of them agonist decrease a receptors production.
An agonist can be twice as strong if an antagonist is used first
Allowing the agonist to have more receptors for the agonist to bind too. This is used in pain clinics to lower dosage and tolerance in the patient.

Antagonist can also the block the action of an agonist from binding

Reuptake inhibitors can block an agonist because the Neurochemical is in the way for the agonist to bind to it.

This video shows alot of about Neurochemical
https://youtu.be/S-NukJp_Nbs
------
Nicotinic acetylcholine receptors can be blocked by curare, hexamethonium and toxins present in the venoms of snakes and shellfishes, like α-bungarotoxin

---------
==================
A bit of topic
The connection between the body and brain actually go both ways

Psychological states

Psychogenic illness/Conversion disorder

Symptoms
Numbness, weakness, paralysis, seizures, tremor, fainting, impaired hearing, swallowing and vision.

Impaired coordination or balance
Weakness/paralysis of a limb or the entire body (hysterical paralysis or motor conversion disorders)
Impairment or loss of speech (hysterical aphonia)
Difficulty swallowing (dysphagia) or a sensation of a lump in the throat
Urinary retention
Psychogenic non-epileptic seizures or convulsions
Persistent dystonia
Tremor, myoclonus or other movement disorders
Gait problems (astasia-abasia)
Loss of consciousness (fainting)
Sensory symptoms or deficits:

Impaired vision (hysterical blindness), double vision
Impaired hearing (deafness)
Loss or disturbance of touch or pain sensation
--------------

physical symptoms of depression
-Psychogenic pain - common in severe depression a physical sensation of pain originating from the depression.

physical symptoms of anxiety

-psychogenic amnesia - memory loss due to anxiety

-Psychogenic heart attack - originate from the extreme form of a panic attack
psychogenic seizure - originate from the extreme form of a panic attack
-Psychogenic tremor - originate from the extreme form of a panic attack

[Edited on 8-5-2021 by symboom]

Mr. Rik - 9-5-2021 at 18:35

This is absolutetly impressive. I would like to learn more about the methods you use for extraction, preservation and handling of your plant materials. I am extremely interested in this subject because we are restoring an old citrus orchard in the tropics and the array of diversity is incredible, more so when you consider that even the tiniest weed can rid you of worms or contain otherwise interesting components.

symboom - 9-5-2021 at 20:41

Here is a list of natural nmda antagonists
http://www.sciencemadness.org/talk/viewthread.php?tid=155429

Here are a list of natural antidepressants https://youtu.be/9nt67gj43ug

I try to keep things sterile I've havnt done any extraction of pure compounds been too busy. I've just made solution of the herb by using an ultrasonic bath and some everclear
I have a small 30W dehumidifier and try to save the silica gel packs I try to keep a sterile environment. Mold is aggressive in humid environments. I found that alot of this information was scattered around so I tried to compile it from scientific papers which paywalls are a real pain.

[Edited on 10-5-2021 by symboom]

[Edited on 11-5-2021 by symboom]