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Author: Subject: The neurochemicals in nature
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biggrin.gif posted on 4-4-2018 at 22:43
The neurochemicals in nature



I have been working on a project took a while in categorizing herbs in what general receptors are activated



Serotonin
Dopamine
Adrenaline
NMDA
Opioid
Histamine



Nmda antagonist

Psychotria colorata
psychotridine
hodgkinsine

Psychotria lyciiflora
hodgkinsine
quadrigemine C
isopsychotridine B
psychotridine
quadrigemine
oleoidine
caledonine

Calycodendron milnei
Hodgkinsine

Tabernaemontana divaricata
conolidine
tabernaemontanine,
coronarine,
coronaridine,
dregamine.

Acourous calamus
alpha-asarone,
beta-asarone
gamma-asarone

Hodgkinsonia frutescens
Hodgkinsine

Cats claw
Rhyncophylline
speciophylline
uncarine F
pteropodine
isopteropodine
mitraphylline
isomitraphylline
 Isorhynchophylline

Sophora flavescens
Matrine
matrine oxide,
Kushenin
Sophoraflavanone
7,9,2',4'-Tetrahydroxy-8-isopentenyl-5-methoxychalcone
Sophoridine
Trifolirhizin,
8-Prenylkaempferol
Oxysophocarpine
sophocarpine

Corydalis yanhusuo
Dehydrocorybulbine
Glaucine

Glaucium flavum
Glaucine

Croton lechleri
Glaucine

Stephania rotunda
Tetrahydropalmatine

pukatea
Pukateine

Phellodendron amurense
Hodgkinsine

Galbulimima belgraveana
himbacine
Himgrina
Himgravina
Himandravina
Himbelina

Zizyphus jujuba
Sanjoinine A

Cyperus articulatus
alpha-corymbolol,
alpha-cyperone,
alpha-pinene
carophyllene oxide
corymbolone
Cyperotundone,
mustakone.
Cyperotundone
alpha-cyperone.
Articulone, 
copaene, 
α-corymbolol, 
β-corymbolone, 
mandassidione 
caryophyllene oxide,
trans-pinocarveol,
myrtenal,
myrtenol,
ledol,
Cyperotundone,
alpha-cyperone

Bacopa monnieri
brahmine,
nicotine,
herpestine
D-mannitol,
apigenin,
hersaponin,
monnierasi
bacopaside I
bacoside A3
bacopaside II
bacopasaponin C

Searsia pyroides ethanol extract also depressed the NMDA stimulated increase in intracellular Ca.

Dangers
K hole

NMDA agonist
Dangers
Glutamate toxity

Alanine

Aspartic acid

Glutamic acid

Glycine

Serine

Seritonin agonist
Antidepression
The tryptamine psychedelics, such as DMT and psilocybin, structurally resemble serotonin itself. The phenethylamine psychedelics on the other hand, such as mescaline, and compounds of the 2C family, more closely resemble the neurotransmitter dopamine.


Sceletium tortuosum
mesembrine,
mesembrenone
mesembrenol
Tortuosamine.

Lespedeza bicolor

Yopo
2,9-dimethyltryptoline
2-methyltryptoline
5-MeO-DMT
5-Methoxy-N-methyltryptamine
Bufotenin
Bufotenin-oxide
Catechol
Leucoanthocyanin
Leucopelargonidol
DMT
DMT-oxide
Methyltryptamine
Orientin
Saponarentin
Viterine

Fittonia albivenis

Justicia pectoralis

Prestonia amazonica

Acacia acuminata

Albizia inundata

Voacanga africana

Prestonia amazonica

Delosperma cooperi

Serotonin antagonist

Reserpine Depletes serotonin stores in the brain, heart, and many other organs

Feverfew

red panax ginseng

chastetree

Dopamine agonist
antiparkinson agents are normally agonists and treat ADHD

L-phenylalanine,

L-tyrosine

l_dopa

Mucuna pruriens
L_dopa

Vicia faba
L_dopa

Ulvaria obscura
L_dopa

Chaenomeles speciosa
(Flowering Quince)

Chaenomeles sinensis

Oroxylum indicum
Oroxylin A

Scutellaria baicalensis (Skullcap)
Oroxylin

Dopamine antagonist
Antipsychotics

dopamine antagonists, and as such they have found use in treating schizophrenia, bipolar disorder, and stimulant psychosis


Gaba antagonist
thujone

Thujone
mugwort,
oregano,
common sage
Artemisia absinthium

ginkgo biloba
ginkgolic acids
adipostatin A

kudzu
puerarin
daidzein,
daidzin
genistein
mirificin
salvianolic acid

muira puama
Coumarin,
lupeol
muirapuamine.


Gaba agonist

Amanita muscaria
ibotenic acid
muscimol

Skullcap
wogonin,
wogonoside, 
baicalin,
apigenin,
oroxylin A,
scutellarein,
skullcapflavone.


ashwagandha
tropine
cuscohygrine
withaferin A,


chamomile
Apigenin

Albizza juberilone

Kava
ncluding kavain,
dihydrokavain,
methysticin,
dihydromethysticin,
yangonin,
desmethoxyyangonin
flavokavain A,
flavokavain B
Flavokavain C


Adrenergic agonist

Betel nut (areca nut, paan)
Arecoline

Tobacco
Nicotine

butcher's broom
ruscogenin
neoruscogenin

bitter oranage
N-methyltyramine,
octopamine 
synephrine


bitter yam

coca (cocaine)
Benzoylecgonine
Cocaine
Ecgonidine
Ecgonine
Hydroxytropacocaine
Methylecgonine cinnamate
Tropacocaine
Truxilline
Cuscohygrine
Dihydrocuscohygrine
Hygrine
Nicotine

ephedra.
ephedrine
pseudoephedrine
norephedrine,
Norpseudoephedrine

Acorus calamus
alpha-asarone
Beta-asarone
gamma-asarone
eugenol

Anamirta cocculus
berberine,
palmatine,
magnoflorine
columbamine


Areca catechu
arecaidine
arecoline,
................
Catuaba
What gives strength to the indian


Trichilia catigua
Cinchonain-Ib

Erythroxylum vaccinifolium.
catuabines.


Other catuaba preparations use the bark of trees from the following genera or families: Anemopaegma, Ilex, Micropholis, Phyllanthus, Secondatia, Tetragastris and species from the Myrtaceae

Holly
caffeic acid,
caffeoyl derivatives,
caffeoylshikimic acid,
Chlorogenic acid,
Feruloylquinic acid,
quercetin,
quinic acid,
kaempferol,
tannins
, rutin,
caffeine
theobromine


...........


chocolate
Theobromide

Contrayerva
contrajervin
cajapine,
dorsjervin A,
dorsjervin B,
psoralen,
dorstenin,
squalene,
γ-sitosterol,
cycloartocarpesin,
1-O-linolenoyl-2-O-stearoyl-3-O-ß-D-galactopyranosyl glycerol,
bergapten,
dorsteniol,
xanthoarnol

Guarana
caffeine
theophylline
Theobromine

Khat
cathinone
cathine

Nicotiana rustica
nicotine nine times more than common tobacco
Harman
norharman


Sida cordifolia
ilima flannel weed, bala, country mallow or heart-leaf sida mallow family
β-phenethylamine
Ephedrine,
pseudo-ephedrine
hypaphorine,
vasicinone,
vasicinol,
choline
betaine.


Tea
4% caffeine
theobromine.


Tobacco
Nicotine
rutin
chlorogenic acid
glutamic acids,
asparagine
, glutamine
γ-Aminobutyric acid
Nornicotine
anatabine
anabasine,
myosmine
cotinine



Yerba mate
Caffeine,
theobromine
theophylline

Yohimbe
yohimbine.
corynanthine

Indian snake root
Rauvolfia serpentina
ajmaline
, ajmalicine,.
ajmalimine,
deserpidine,
indobine,
indobinine,
reserpine,
reserpiline,
rescinnamine,
rescinnamidine,
serpentine,
serpentinine
yohimbine.




Adrenergic antagonist

???


Anticholinergic
spasmolytic, anti-asthmatic, anticholinergic, narcotic and anesthetic

Hyoscyamus niger,

Atropa belladonna,

Mandragora officinarum
hyoscyamine
, hyoscine,
cuscohygrine,
apoatropine,
3-alpha-tigloyloxytropane
, 3-alpha,6-beta-ditigloyloxytropane
belladonnine

Datura

Tassel bush

Nutmeg

Canarium luzonicum

Amanita muscaria


Cholinergic

lemon balm,

sage,

rosemary,

ginkgo,

gotu kola

Chinese club moss

Vinca minor
Vincaminol
vincamine.
reserpine
, reserpinine
, akuammicine
, majdine,
vinerine,
ervine,
vineridine,
tombozine,
vincamajine,
vincanine,
vincanidine,
vincamone,
apovincamine,
vincaminol,
desoxyvincaminol,
vincorine
perivincine.


Nootropics
Alpha-GPC (

Citicoline

Galanthus caucasicus

Tyrosine

Creatine


Histamine agonist?
???

Histamine antagonist
Stinging Nettle
Quercetin.
Bromelain.
Vitamin C.


Opiate agonist

Opium poppy

Kratom

Akuamma
akuammidine,
akuammine,
akuammicine,
akuammigine
pseudoakuammigine.

Periwinkle

Nauclea latifolia
Tramadol

Dalea purpurea
pawhuskin A,
pawhuskin B,
pawhuskin C,
Petalostemumol

Salvia divitorium


Commiphora Myrrh
furanoeudesma-1,3-diene

Peripentadenia Mearsii
- peripentonine A, B, and C,
peripentadenine
mearsamine
Peripentadenine,


Psychotria Colorata
Psychotridine
Hodgkinsine



Nigella Sativa
thymoquinone

Stephania japonica
-8 Hasubanan alkaloids and 1 morphinane alkaloid have been isolated from this vine.

Actaea racemosa-Contains a partial mu-opioid agonist.

Elaeocarpus grandis
grandisine A, B, C, D, E, F, G
isoelaeocarpiline.

Elaeocarpus fuscoides-
elaeocarpenine,
isoelaeocarpicine
, isoelaeocarpine
elaeocarpine .


Opiate antagonist?
???

Cannabinoid agonist
Liverwort
Perrottetinene
Perrottetinic acid


Coneflower – Echinacea
cannabimimetic
N-alkyl amides


Oxeye - Heliopsis helianthoides
cannabimimetic
N-alkyl amides


Electric daisy - Acmella oleracea
N-Isobutylamides


Helichrysum umbraculigerum
cannabigerol


Liverwort – Radula marginata
perrottetinenic acid is remarkably similar to THC.

Chocolate

FAAH is responsible for the breakdown of an endocannabinoid known as anandamide in our bodies. Anandamide is our natural version of THC


Black pepper- Piper nigrum
Beta-caryophyllene (BCP)


Herbs found to engage with the endocannabinoid system. A couple others include Peruvian maca and Chinese rhododendron.

Refrences
https://herb.co/marijuana/news/non-marijuana-plants-contain-...

Efficacy_spectrum.png - 17kB

[

Agonists_and_antagonists.png - 24kB


[Edited on 5-4-2018 by symboom]

[Edited on 5-4-2018 by symboom]




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rase
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[*] posted on 25-3-2019 at 15:45
nice list


Hello,

nice list you have there...

can you tell whats the best sources for that herbs?

Thanks
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[*] posted on 25-3-2019 at 17:20


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