HankTheHam
Harmless
Posts: 5
Registered: 7-3-2014
Member Is Offline
Mood: No Mood
|
|
Phenol to salicaldahyde how?
I’m trying to convert aspirin to benzaldehyde and I have it all figured out except for the conversion of phenol to salicaldehyde then salicaldehyde
to benzaldehyde I know about the Reimer–Tiemann reaction and that’s the route I’m wanting to take so if anyone here has any experience with this
help with the set up and measurements of chemicals would be appreciated
Edit:Never mind I found a paper on this that explains everything in good detail from what I have heard this reaction is a horrible way to prepare
salicaldehyde so I’m going to do it just for the challenge
[Edited on 13-7-2023 by HankTheHam]
[Edited on 13-7-2023 by HankTheHam]
|
|
|
arkoma
Redneck Overlord
Posts: 1761
Registered: 3-2-2014
Location: On a Big Blue Marble hurtling through space
Member Is Offline
Mood: украї́нська
|
|
From here https://www.sciencemadness.org/madscifaq.html#2.1_Board_topi...
| Quote: | Do not request spoonfeeding of information for clandestine drug manufacture. However, every sort of chemistry is a permissible topic of discussion if
you discuss it like a scientist. If someone is asking about obtaining chemicals used in drug manufacture and using the vocabulary of a SWIM—"someone
who isn't me"—-mer more than a chemist, report it and the thread will be dealt with after a moderator has confirmed your findings. Similarly, if
someone is asking for help with a synthetic "recipe" for a known street drug, report that too. Don't bother to berate the cooks in the thread itself
instead; that doesn't bring the mods any faster. In truth the mods and most members dislike any thread where someone is seeking or using a "recipe"
and doesn't show any deeper interest in chemistry, but this has been mostly a problem with drug synthesis because of the many people who want to
quickly get rich or high.
|
Also, our site search engine sucks. use | Code: | site:sciencemadness.org search term |
in google
"We believe the knowledge and cultural heritage of mankind should be accessible to all people around the world, regardless of their wealth, social
status, nationality, citizenship, etc" z-lib
|
|
|
RustyShackleford
Hazard to Others
Posts: 195
Registered: 10-12-2020
Location: Northern Europe
Member Is Offline
|
|
Dont do reimer tiemann, it blows. i posted about my experience here: http://www.sciencemadness.org/talk/viewthread.php?tid=61964&...
i recommend doing the Mg mediated formylation instead.
|
|
|
HankTheHam
Harmless
Posts: 5
Registered: 7-3-2014
Member Is Offline
Mood: No Mood
|
|
Alright upon further analysis my post sounds really sketchy I’m not a meth head looking for a quick high or someone looking to make money I’m just
a really Amateur chemist who had an idea for a project I didn’t think about it too hard I was smelling some almond extract and liked the smell
knowing it was benzaldehyde producing the smell I put together the outline to a synthesis of benzaldehyde from aspirin I’m pretty amateur so I
don’t have a big chemist vocabulary so I came here asking for some help on a step I was stuck on sorry about my demeanor
|
|
|
clearly_not_atara
International Hazard
Posts: 2699
Registered: 3-11-2013
Member Is Offline
Mood: Big
|
|
The ortho-formylation of interest in drug synthesis is just one of five or six steps, depending on the precursors, and it's one of the easier ones.
Furthermore, you don't start with plain phenol.
So I don't think that this particular reaction should be so scrutinized, particularly since the OP didn't even mention the compound which is actually
a precursor.
Salicylaldehyde to benzaldehyde is likely to be very hard, though. Consider a different target.
[Edited on 04-20-1969 by clearly_not_atara]
|
|
|
![[*]](images/xpblue/default_icon.gif){kind=icon}
