kekule
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Registered: 18-1-2006
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help with amine-->>>imine chemistry
I am trying to react and aldehyde (formaldehyde) with a primary amine (L-Lysine) to yield an imine adduct. These imine -like compounds form at the
greatest rate at pH of around 5. Water is a by-product, and removal of water yields the imine. I assume water as a solvent should be avoided, since
imines are easily hydrolysed. My problem is, L-lysine seems to be insoluble in everthing EXCEPT water! Formalin also contains water, but I can get
around that by generating formaldehyde gas. Any suggestions as to how to perform this condensation without water?
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solo
International Hazard
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Location: Estados Unidos de La Republica Mexicana
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Formaldehyde/amine adduct , United States Patent 5030762
Abstract: A formaldehyde/amine adduct useful in water treatment having improved stability made by reacting formaldehyde and a
secondary amine, limiting the water content of the adduct to no more that 30 weight percent, optionally, adding an alcohol
It's better to die on your feet, than live on your knees....Emiliano Zapata.
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emrebjk
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dean stark apparatus maybe your solution
if you use dean stark with toluen/water mixture (you can change toluen with anytihing which boiling point is higher than water and density is lower).
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